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3-苯基丙烯腈

3-苯基丙烯腈用途

在日化香精的配制中，对于使用于碱性介质的加香，此化合物具有比桂醛等更为优越的原料。

3-苯基丙烯腈名称

[ CAS 号 ]:
4360-47-8

[ 中文名 ]:
肉桂腈

[ 英文名 ]:
Cinnamonitrile

[中文别名 ]:

[英文别名 ]:

2-Propenenitrile,3-phenyl-
EINECS 224-441-5
MFCD00001930

3-苯基丙烯腈物理化学性质

[ 密度 ]:
1.028 g/mL at 25ºC(lit.)

[ 沸点 ]:
254-255ºC

[ 熔点 ]:
18-20ºC

[ 分子式 ]:
C₉H₇N

[ 分子量 ]:
129.15900

[ 闪点 ]:
>230 oF

[ 精确质量 ]:
129.05800

[ PSA ]:
23.79000

[ LogP ]:
2.22338

[ 折射率 ]:
n20/D 1.601(lit.)

[ 储存条件 ]:
室温

3-苯基丙烯腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD1440000

CHEMICAL NAME :: 2-Propenenitrile, 3-phenyl-

CAS REGISTRY NUMBER :: 4360-47-8

BEILSTEIN REFERENCE NO. :: 1209545

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H7-N

MOLECULAR WEIGHT :: 129.17

WISWESSER LINE NOTATION :: NC1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,721,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,721,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 153,895,1911

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 153,895,1911

3-苯基丙烯腈安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26;S36

[ WGK德国 ]:
3

[ RTECS号 ]:
UD1440000

[ 包装等级 ]:
III

3-苯基丙烯腈合成路线

详细合成路线

3-苯基丙烯腈上下游产品

3-苯基丙烯腈上游产品

3-苯基丙烯腈下游产品

3-苯基丙烯腈制备

１、用苯乙烯基溴和氰化钾法。

２、醛肟脱水制备法等，很多方法前者为经典方法，方便得率高，缺点为使用剧毒的试剂。后者的方法较为常用，因为醛制成肟后脱水转化为腈，脱水剂可用醋酐、磷酐苯甲铣氯、三氟醋酸、吡啶原甲酸三乙酯、氯化三磷氮（P３Ｎ３Ｃｌ３）等，都能达到目的。