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5-羟甲基脲嘧啶

5-羟甲基脲嘧啶用途

5-Hydroxymethyluracil 是氧化性 DNA 损伤的产物。5-Hydroxymethyluracil 可用作增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。

5-羟甲基脲嘧啶名称

[ CAS 号 ]:
4433-40-3

[ 中文名 ]:
5-羟甲基尿嘧啶

[ 英文名 ]:
5-Hydroxymethyluracil

[中文别名 ]:

[英文别名 ]:

5-(hydroxymethyl)-1H-pyrimidine-2,4-dione
EINECS 224-636-5
2,4-Pyrimidinediol, 5-(hydroxymethyl)-
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
5-hydroxymethyluracil
MFCD00056024
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-
5-(hydroxymethyl)-1,3-dihydropyrimidine-2,4-dione
5-(Hydroxymethyl)uracil
5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione

5-羟甲基脲嘧啶生物活性

[ 描述 ]:

5-Hydroxymethyluracil 是氧化性 DNA 损伤的产物。5-Hydroxymethyluracil 可用作增强或抑制细菌 RNA 聚合酶转录的潜在表观遗传标记。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91.

[2]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255.

[相关活性小分子]

5-羟甲基脲嘧啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
530.4ºC at 760mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₅H₆N₂O₃

[ 分子量 ]:
142.113

[ 闪点 ]:
274.6ºC

[ 精确质量 ]:
142.037842

[ PSA ]:
86.47000

[ LogP ]:
-0.50

[ 折射率 ]:
1.528

[ 储存条件 ]:
Refrigerator

5-羟甲基脲嘧啶MSDS

5-羟甲基脲嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR0513000

CHEMICAL NAME :: Uracil, 5-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 4433-40-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C5-H6-N2-O3

MOLECULAR WEIGHT :: 142.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 400 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,5466,1988

5-羟甲基脲嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YR0513000

[ 海关编码 ]:
2933599090

5-羟甲基脲嘧啶合成路线

5-羟甲基脲嘧啶上下游产品

5-羟甲基脲嘧啶上游产品

5-羟甲基脲嘧啶下游产品

5-羟甲基脲嘧啶海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟甲基脲嘧啶文献

Measurement of urinary excretion of 5-hydroxymethyluracil in human by GC/NICI/MS: correlation with cigarette smoking, urinary TBARS and etheno DNA adduct.

Toxicol. Lett. 155(3) , 403-10, (2005)

5-Hydroxymethyluracil (5-HMU) is derived from radiation in addition to endogenous oxidative DNA damage and it is one of the most abundant DNA adducts. Human 5-HMU-DNA-glycosylase has been shown to rep...

Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase.

Nucleic Acids Res. 32(17) , 5291-302, (2004)

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-h...

Qualitative and quantitative analyses of the decomposition products that arise from the exposure of thymine to monochromatic ultrasoft X rays and 60Co gamma rays in the solid state.

Radiat. Res. 161(4) , 442-50, (2004)

HPLC analyses of condensed thymine irradiated with monochromatic synchrotron ultrasoft X rays in the energy region around nitrogen and oxygen K-shell edges were performed. Cobalt-60 gamma rays were us...

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