卡波霉素
卡波霉素名称
[ CAS 号 ]:
4564-87-8
[ 中文名 ]:
卡波霉素
[ 英文名 ]:
Leucomycin V,9-deoxy-12,13-epoxy-12,13-dihydro-9-oxo-, 3-acetate 4B-(3-methylbutanoate),(12S,13S)-
[英文别名 ]:
- DeltaMycin A4
- M 4209
- Magnamycin-A
- MagnaMycin
- carbomycin
- CarboMycin A
卡波霉素物理化学性质
[ 密度 ]:
1.24g/cm3
[ 沸点 ]:
892.2ºC at 760mmHg
[ 熔点 ]:
214ºC
[ 分子式 ]:
C42H67NO16
[ 分子量 ]:
841.97800
[ 闪点 ]:
493.4ºC
[ 精确质量 ]:
841.44600
[ PSA ]:
215.42000
[ LogP ]:
2.43280
[ 折射率 ]:
1.535
[ 储存条件 ]:
库房低温通风干燥
卡波霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OH4727000
- CHEMICAL NAME :
- Leucomycin V, 9-deoxy-12,13-epoxy-12,13-dihydro-9-oxo-, 3-acetate 4B-(3-methylbutanoate), (12S,13S)-
- CAS REGISTRY NUMBER :
- 4564-87-8
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C42-H67-N-O16
- MOLECULAR WEIGHT :
- 842.10
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,336,1954/1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 3,117,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 3,117,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 3,117,1953
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