腺苷酸二钠盐

腺苷酸二钠盐用途

腺苷5'-单磷酸二钠是一种口服活性嘌呤核苷酸,参与ATP代谢。腺苷5'-单磷酸二钠也是腺苷2B受体的配体。腺苷5'-单磷酸二钠可以激活骨骼肌中的AMPK,改善胰岛素抵抗和糖代谢受损。腺苷5'-单磷酸二钠可用于糖尿病的研究[1][2][3]。

腺苷酸二钠盐名称

[ CAS 号 ]:
4578-31-8

[ 中文名 ]:
5'-腺嘌呤核苷酸二钠盐

[ 英文名 ]:
Adenosine 5′-monophosphate disodium salt

[中文别名 ]:

[英文别名 ]:

Disodium 5'-O-phosphonatoadenosine
Disodium adenosine 5'-phosphate
Adenosine 5'-monophosphate disodium salt
MFCD00065023
Adenosine-5'-monophosphate disodium salt
Adenosine 5′-monophosphate sodium salt
AMP disodium salt
EINECS 224-961-2
5'-Adenylic acid, sodium salt (1:2)
5'-AMP-Na2

腺苷酸二钠盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

A2BR

[体内研究]

5'-单磷酸腺苷(10和 13mg/L添加在蒸馏水中,25周) 二钠改善高频数据诱导的糖尿病小鼠的葡萄糖代谢[1]。 5'-单磷酸腺苷(40-800 mg/kg,腹腔注射)二钠通过小鼠体内的腺苷受体降低体温[2]。动物模型：患有高脂饮食诱导的糖尿病的C57BL/6 J小鼠[1]剂量：10和13 mg/L给药：在蒸馏水中添加,持续25周结果：骨骼肌中AMPK的磷酸化和参与脂质氧化的基因的mRNA水平增强。

[参考文献]

[1]. Ardiansyah, et al. Adenosine and adenosine-5'-monophosphate ingestion ameliorates abnormal glucose metabolism in mice fed a high-fat diet. BMC Complement Altern Med. 2018 Nov 14;18(1):304.

[2]. Steven J. Swoap, et al. AMP does not induce torpor. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2007 293:1, R468-R473.

[3]. Holien JK, et al. AMP and adenosine are both ligands for adenosine 2B receptor signaling. Bioorg Med Chem Lett. 2018 Jan 15;28(2):202-206.

腺苷酸二钠盐物理化学性质

[ 沸点 ]:
798.5ºC at 760 mmHg

[ 熔点 ]:
232-235ºC

[ 分子式 ]:
C₁₀H₁₂N₅Na₂O₇P

[ 分子量 ]:
391.185

[ 闪点 ]:
436.7ºC

[ 精确质量 ]:
391.026978

[ PSA ]:
201.54000

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: soluble

腺苷酸二钠盐MSDS

详细MSDS(安全技术说明书)

腺苷酸二钠盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7481600

CHEMICAL NAME :: 5'-Adenylic acid, disodium salt

CAS REGISTRY NUMBER :: 4578-31-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N5-O7-P.2Na

MOLECULAR WEIGHT :: 391.22

WISWESSER LINE NOTATION :: T56 BM DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPO&O&O &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 33,24,1974

腺苷酸二钠盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU7481600

腺苷酸二钠盐合成路线

详细合成路线

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腺苷酸二钠盐文献

Regulation of AMPK by the ubiquitin proteasome system.

Am. J. Pathol. 178 , 4-11, (2011)

The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinat...

New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK.

Clin. Cancer Res. 16 , 3322-3328, (2010)

Although the role of metabolic syndrome (MS) and a high fat diet in prostate cancer (PCa) risk is still a matter of intense debate, it is becoming increasingly clear that obesity can cause perturbatio...

Identification of a novel CaMKK substrate.

Biochem. Biophys. Res. Commun. 410 , 45-51, (2011)

Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates specific downstream protein kinases including CaMKI, CaMKIV and 5'-AMP-activated protein kinase. In order to exam...

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