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二甲氨基氯乙烷盐酸

二甲氨基氯乙烷盐酸用途

【用途一】
用于生产硅油、硅橡胶等
【用途二】
用作有机合成、医药中间体
【用途三】
医药中间体。用于生产抗组胺药盐酸派力本沙明。

二甲氨基氯乙烷盐酸名称

[ CAS 号 ]:
4584-46-7

[ 中文名 ]:
二甲氨基氯乙烷盐酸

[ 英文名 ]:
(2-Chloroethyl)dimethylamine hydrochloride

[中文别名 ]:

[英文别名 ]:

N-(2-chloroethyl)-N,N-dimethylamine hydrochloride
DMC-HCl
MFCD00012516
(β-Chloroethyl)dimethylamine hydrochloride
2-(dimethylamino)-ethylchloride hydrochloride
N,N-Dimethyl-2-ChloroethylamineHCl
2-(N,N-dimethylamino)ethylchloride hydrochloride
DIMETHYLAMINOETHYLCHLORIDE HCL
DMC
2-Chloro-N,N-dimethylethylamine Hydrochloride

二甲氨基氯乙烷盐酸物理化学性质

[ 沸点 ]:
57.8ºC at 760 mmHg

[ 熔点 ]:
201-204 °C(lit.)

[ 分子式 ]:
C₄H₁₁Cl₂N

[ 分子量 ]:
144.043

[ 闪点 ]:
21.6ºC

[ 精确质量 ]:
143.026855

[ PSA ]:
3.24000

[ LogP ]:
1.58880

[ 外观性状 ]:
无色至米色晶体

[ 水溶解性 ]:
2000 g/L (20 ºC)

二甲氨基氯乙烷盐酸MSDS

详细MSDS(安全技术说明书)

二甲氨基氯乙烷盐酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KQ9020000

CHEMICAL NAME :: Ethylamine, 2-chloro-N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 4584-46-7

LAST UPDATED :: 199804

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C4-H10-Cl-N.Cl-H

MOLECULAR WEIGHT :: 144.06

WISWESSER LINE NOTATION :: G2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 238 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Gastrointestinal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 mg/kg/7D-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - hepatitis (hepatocellular necrosis), diffuse Nutritional and Gross Metabolic - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 100 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1697,1987

二甲氨基氯乙烷盐酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P312

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R22;R24;R26;R36/37/38;R51/53;R68

[ 安全声明 (欧洲) ]:
S26-S36/37-S45-S61-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
KQ9020000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29211980

二甲氨基氯乙烷盐酸合成路线

详细合成路线

二甲氨基氯乙烷盐酸上下游产品

二甲氨基氯乙烷盐酸上游产品

二甲氨基氯乙烷盐酸下游产品

二甲氨基氯乙烷盐酸制备

由二甲胺经与氯乙酐缩合、氯化亚砜氯化而得。

二甲氨基氯乙烷盐酸海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%