<生产厂家价格>

2-丁烯腈

2-丁烯腈名称

[ CAS 号 ]:
4786-20-3

[ 中文名 ]:
2-丁烯腈

[ 英文名 ]:
crotononitrile

[中文别名 ]:

巴豆腈

[英文别名 ]:

EINECS 225-335-1
(2E)-2-Butenenitrile
(2E)-But-2-enenitrile
Crotononitrile (pract)
MFCD00001935
cis-β-Methylacrylonitrile
(E)-2-Butenenitrile
crotononitrile
But-2-Enenitrile
2-Butenenitrile, (2E)-

2-丁烯腈物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
120.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-51.5ºC

[ 分子式 ]:
C₄H₅N

[ 分子量 ]:
67.089

[ 闪点 ]:
20.0±0.0 °C

[ 精确质量 ]:
67.042198

[ PSA ]:
23.79000

[ LogP ]:
0.71

[ 外观性状 ]:
透明淡黄色液体

[ 蒸汽压 ]:
15.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.418

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类、食品添加剂分开存放

2-丁烯腈MSDS

详细MSDS(安全技术说明书)

2-丁烯腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ6322000

CHEMICAL NAME :: Crotononitrile

CAS REGISTRY NUMBER :: 4786-20-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C4-H5-N

MOLECULAR WEIGHT :: 67.10

WISWESSER LINE NOTATION :: NC1U2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 501 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(4),10,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 396 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(4),10,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 153,895,1911

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 272 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(4),10,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 153,895,1911 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 91 mg/kg/26W-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 37(4),10,1972

2-丁烯腈安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;F: Flammable;

[ 风险声明 (欧洲) ]:
R16;R26;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S36

[ 危险品运输编码 ]:
UN 2924 3/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
GQ6322000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.1

2-丁烯腈文献

Comparative developmental toxicities of aliphatic nitriles: in vivo and in vitro observations.

Toxicol. Appl. Pharmacol. 163(2) , 149-63, (2000)

The effects on embryonic development of a series of eight saturated (acetonitrile, propionitrile, and n-butyronitrile) and unsaturated (acrylonitrile, methacrylonitrile, allylnitrile, cis-2-pentenenit...

A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents.

Food Chem. Toxicol. 49(3) , 563-70, (2011)

Konzo and lathyrism are associated with consumption of cassava and grass pea, respectively. Cassava consumption has also been associated with a third disease, tropical ataxic neuropathy (TAN). This re...

Relative developmental toxicities of inhaled aliphatic mononitriles in rats.

Fundam. Appl. Toxicol. 20(3) , 365-75, (1993)

The developmental toxicities of eight aliphatic mononitriles were studied in Sprague-Dawley rats after inhalation exposure for 6 hr/day, during Days 6 to 20 of gestation. The range of exposure concent...

更多文献