氯酯醒

氯酯醒用途

氯酯醒为中枢神经经兴奋药。主要作用于大脑皮质，促进脑细胞氧化还原，增加糖的利用，能调节神经细胞代谢，促进抑制状态的神经系统的兴奋，是种有效的刺激精神、抑制疲倦的药物。其作用产生较缓慢，反复使用后效果才较显著。适用于意识障碍、颅脑外作性昏迷、新生儿缺氧症、儿童遗尿症、酒精中毒、才年性精神障碍及某些其他神经性疾病。

氯酯醒名称

[ CAS 号 ]:
51-68-3

[ 中文名 ]:
氯酯醒

[ 英文名 ]:
2-(Dimethylamino)ethyl (4-chlorphenoxy)acetate

[中文别名 ]:

遗尿丁

[英文别名 ]:

EINECS 200-116-3
Clofenoxin
meclofenoxate
DMAE p-chlorophenoxyacetate
Meclophenoxate
centrophenoxine
Clopenoxin
Deanolestere
meclofenaxate
Cetrexin

氯酯醒物理化学性质

[ 密度 ]:
1.178g/cm3

[ 沸点 ]:
345.9ºC at 760mmHg

[ 分子式 ]:
C₁₂H₁₆ClNO₃

[ 分子量 ]:
257.71300

[ 闪点 ]:
163ºC

[ 精确质量 ]:
257.08200

[ PSA ]:
38.77000

[ LogP ]:
1.82360

[ 折射率 ]:
1.52

氯酯醒毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG0430000

CHEMICAL NAME :: Acetic acid, (p-chlorophenoxy)-, 2-(dimethylamino)ethyl ester

CAS REGISTRY NUMBER :: 51-68-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H16-Cl-N-O3

MOLECULAR WEIGHT :: 257.74

WISWESSER LINE NOTATION :: GR DO1VO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,386,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,386,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 758 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 38,154,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,386,1972

氯酯醒安全信息

[ 海关编码 ]:
2922509090

氯酯醒合成路线

详细合成路线

氯酯醒制备

由对氯苯氧乙酸与二甲胺基乙醇进行酯化反应制得。将对氯苯氧乙酸、二甲胺基乙醇、间二甲苯及对甲苯磺酸加入反应锅，搅拌加热，在145℃脱水反应至无水滴蒸出为止。冷至40℃，加活性炭脱色。再冷至5℃左右，通入干燥的氯化氢气体，先析出黄色油状物，为过量的二甲胺基乙醇盐酸盐，然后析出氯酯醒盐酸盐，直到溶液呈强酸性为止。再将下层油状物分离，上层白色结晶冷冻过滤，结晶用二甲苯洗涤，得粗品。最终经异丙醇重结晶、活性炭脱色得成品。

另一种制备方法是将对氯苯氧乙酸和等摩尔的三乙胺的氯仿溶液混合，在搅拌下滴加三氯氧磷。加毕，继续反应1小时，然后加入等摩尔的二甲胺基乙醇，在25℃反应3h后加水搅匀，用碳酸钠溶液碱化。分离出氯仿层，干燥后回收氯仿，将所得油状物加入含有氯化氢的异丙醇中，析出结晶。经异丙醇重结晶，即得熔点为135-137℃的对氯苯氧乙酸二甲胺基乙酯盐酸盐，收率54%。

氯酯醒海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

氯酯醒