5-DIMETHYLAMINO-6-PROPYL-5H-INDENO(5,6-d)-1,3-DIOXOLE HYDROCHLORIDE

名称

[ CAS 号 ]:
51003-81-7

[ 英文名 ]:
5-DIMETHYLAMINO-6-PROPYL-5H-INDENO(5,6-d)-1,3-DIOXOLE HYDROCHLORIDE

[英文别名 ]:

物理化学性质

[ 分子式 ]:
C15H20ClNO2

[ 分子量 ]:
281.77800

[ 精确质量 ]:
281.11800

[ PSA ]:
21.70000

[ LogP ]:
4.01710

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK8927000
CHEMICAL NAME :
5H-Indeno(5,6-d)-1,3-dioxole, 5-dimethylamino-6-propyl-, hydrochloride
CAS REGISTRY NUMBER :
51003-81-7
LAST UPDATED :
199606
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C15-H19-N-O2.Cl-H
MOLECULAR WEIGHT :
281.81
WISWESSER LINE NOTATION :
T C565 DO FO EH JHJ JN1&1 K3 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - decreased motility or constipation
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1470 mg/kg/4W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 26,85,1979

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