Estra-1,3,5(10)-triene-16,17-diol,3-methoxy-16-methyl-, (16b,17b)-

名称

[ CAS 号 ]:
5108-94-1

[ 英文名 ]:
Estra-1,3,5(10)-triene-16,17-diol,3-methoxy-16-methyl-, (16b,17b)-

[英文别名 ]:

Manvene
Mytatrienediol
16b-Hydroxy-16-methyl-3-methyl ether 17b-estradiol

物理化学性质

[ 密度 ]:
1.156g/cm3

[ 沸点 ]:
451.3ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₈O₃

[ 分子量 ]:
316.43500

[ 闪点 ]:
226.8ºC

[ 精确质量 ]:
316.20400

[ PSA ]:
49.69000

[ LogP ]:
3.27310

[ 折射率 ]:
1.575

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7550000

CHEMICAL NAME :: Estra-1,3,5(10)-triene-16-beta,17-beta-diol, 3-methoxy-16-methyl-

CAS REGISTRY NUMBER :: 5108-94-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H28-O3

MOLECULAR WEIGHT :: 316.48

WISWESSER LINE NOTATION :: L E5 B666TTT&J E1 FQ GQ G1 OO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 35 mg/kg

SEX/DURATION :: female 35 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 63,561,1958

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 30 mg/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: RPHRA6 Recent Progress In Hormone Research. Proceedings of the Laurentian Hormone Conference. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1947- Volume(issue)/page/year: 20,395,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 12 mg/kg

SEX/DURATION :: female 4-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 9,277,1965