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溴硝丙二醇

溴硝丙二醇用途

Bronopol是一种抗菌剂, 具有低毒性 (对哺乳动物) 和高活性 ( 尤其对革兰氏阴性菌)。

溴硝丙二醇名称

[ CAS 号 ]:
52-51-7

[ 中文名 ]:
溴硝丙二醇

[ 英文名 ]:
bronopol

[中文别名 ]:

[英文别名 ]:

UN 3241
MFCD00007390
UNII-6PU1E16C9W
bronopol
EINECS 200-143-0
2-Bromo-2-nitropropane-1,3-diol (Bronopol)
2-Bromo-2-nitro-1,3-propanediol
b-Bromo-b-nitrotrimethyleneglycol
2-bromo-2-nitropropane-1,3-diol
2-Brom-2-nitropropan-1,3-diol

溴硝丙二醇生物活性

[ 描述 ]:

Bronopol是一种抗菌剂, 具有低毒性 (对哺乳动物) 和高活性 ( 尤其对革兰氏阴性菌)。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

溴硝丙二醇物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
358.0±42.0 °C at 760 mmHg

[ 熔点 ]:
130-133 °C(lit.)

[ 分子式 ]:
C₃H₆BrNO₄

[ 分子量 ]:
199.988

[ 闪点 ]:
170.3±27.9 °C

[ 精确质量 ]:
198.948013

[ PSA ]:
86.28000

[ LogP ]:
1.72

[ 外观性状 ]:
白色至略黄色晶体或结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.575

[ 储存条件 ]:
库房通风低温干燥,与食品原料类分开存放

[ 稳定性 ]:
Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture.

[ 水溶解性 ]:
25 g/100 mL (22 ºC)

溴硝丙二醇MSDS

溴硝丙二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY3385000

CHEMICAL NAME :: 1,3-Propanediol, 2-bromo-2-nitro-

CAS REGISTRY NUMBER :: 52-51-7

BEILSTEIN REFERENCE NO. :: 1705868

LAST UPDATED :: 199701

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C3-H6-Br-N-O4

MOLECULAR WEIGHT :: 200.01

WISWESSER LINE NOTATION :: WNXE1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 4(4),47,1980

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/m3/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A542,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 29,3,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 8,1029,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,103,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 11(1),73,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 48 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 8,680,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,30,1976 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 3(3),139,1984 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1235 No. of Facilities: 117 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 5176 (estimated) No. of Female Employees: 4904 (estimated)

溴硝丙二醇安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302 + H312-H315-H318-H335-H410

[ 警示性声明 ]:
P273-P280-P302 + P352 + P312-P305 + P351 + P338 + P310-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R21/22;R37/38;R41;R50

[ 安全声明 (欧洲) ]:
S26-S37/39-S61

[ 危险品运输编码 ]:
UN 3241 4.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
TY3385000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2905590030

溴硝丙二醇合成路线

溴硝丙二醇上下游产品

溴硝丙二醇上游产品

溴硝丙二醇下游产品

溴硝丙二醇制备

由硝基甲烷与甲醛、溴反应而得，有两种操作过程。（1）将硝基甲烷、30%甲醛、氯化钙和氢氧化钠按摩尔配比1：2：2：2加入反应装置，搅拌，在0℃以下滴加溴和二氯乙烷配成的溶液。在1h加完，溴的用量与硝基甲烷等摩尔。分出二氯乙烷层，蒸去二氯乙烷。得白色固体（粗品）。反应物的水层用乙醚提取，蒸去乙醚提取液中的乙醚，又得一部分粗品。将粗品合并用乙醚重结晶，即得纯品。（2）先制备2-硝基-1,3-丙二醇将硝基甲烷、30%甲醛溶液按摩尔比1：2加入回流反应装置，再加入2%碳酸钾，加热回流1h，冷却、析出结晶。用乙醚提取，干燥，蒸去乙醚，得2-硝基-1,3-丙二醇。然后将其溶解在甲醇中，加入20%甲醇钠甲醇溶液，在20℃搅拌，析出2-硝基-1,3-丙二醇钠。将此钠盐滤出，悬浮于干燥的乙醚中溴化：在0℃以下向2-硝基-1,3-丙二醇钠的乙醚悬浮液滴加溴，滴完后再搅拌10min。过滤，蒸去乙醚，即得2-溴-2-硝基-1,3-丙二醇。

在反应釜中投入计量的硝基甲烷、甲醛、水和乙醇，冷却下滴加40%液碱，此时有固体析出，再滴加定量溴素，加毕搅拌，减压蒸出部分水和乙醇，经冷却、结晶、过滤、干燥得溴硝醇，收率≥70%，含量约93%。

溴硝丙二醇海关

[ 海关编码 ]: 2905590030

溴硝丙二醇文献

Non-fragrance allergens in specific cosmetic products.

Contact Dermatitis 65(5) , 276-85, (2011)

Reports about the nature of the ingredients responsible for allergic contact dermatitis caused by specific cosmetic products are scarce.Between January 2000 and December 2010, the specific cosmetic pr...

Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives.

J. Am. Acad. Dermatol. 70(1) , 102-7, (2014)

Patients with atopic dermatitis (AD) have chronic dry skin to which they frequently apply skin care products containing preservatives, and they are predisposed to developing cutaneous delayed-type hyp...

Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009).

Contact Dermatitis 65(5) , 286-92, (2011)

Formaldehyde and formaldehyde-releasers are common causes of allergic contact dermatitis.To determine the frequency of sensitization to formaldehyde and seven formaldehyde-releasers. To establish and ...

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