伐灭磷

伐灭磷用途

Famphur is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an agrochemical, and an anthelminthic drug. Use of famphur as an insecticide is restricted.

伐灭磷名称

[ CAS 号 ]:
52-85-7

[ 中文名 ]:
伐灭磷

[ 英文名 ]:
American Cyanamid 38023

[中文别名 ]:

氨磺磷

[英文别名 ]:

Famofos
American Cyanamid CL 38023
MFCD00055307
Fanfos
Warbex
FAMOPHOS
Famphos
Famophos warbex
Dovip
Famphur

伐灭磷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
394.2±52.0 °C at 760 mmHg

[ 熔点 ]:
-96ºC

[ 分子式 ]:
C₁₀H₁₆NO₅PS₂

[ 分子量 ]:
325.341

[ 闪点 ]:
192.2±30.7 °C

[ 精确质量 ]:
325.020752

[ PSA ]:
115.35000

[ LogP ]:
2.13

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

伐灭磷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TF7650000

CHEMICAL NAME :: Phosphorothioic acid, O,O-dimethyl ester, O-ester with p-hydroxy-N,N-dimethylbenzene- sulfonamide

CAS REGISTRY NUMBER :: 52-85-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C10-H16-N-O5-P-S2

MOLECULAR WEIGHT :: 325.36

WISWESSER LINE NOTATION :: 1OPS&O1&OR DSWN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 34,1697,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11600 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 13,366,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued. Volume(issue)/page/year: 9,119,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JDAH "Organophosphorus Pesticides: Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974 Volume(issue)/page/year: -,299,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal)

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(12),94,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Behavioral - muscle contraction or spasticity

REFERENCE :: VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(12),94,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 ug/kg/90D-C

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,167,1999 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 46,1,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

伐灭磷安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H336-H351-H373

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R63

[ 安全声明 (欧洲) ]:
22-24/25-45-36/37-23-53

[ 危险品运输编码 ]:
UN 2783

[ RTECS号 ]:
TF7650000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2935009019

伐灭磷制备

可用二甲氧基硫代磷酰氯与对二甲氨基磺酰基苯酚反应制取。

伐灭磷海关

[ 海关编码 ]: 2935009019

[ 中文概述 ]:
2935009019 畜蜱磷,伐灭磷,地散磷等〔包括磺菌威,氰霜唑〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:35.0%

[ Summary ]:
2935009019 o-(4-(n,n-dimethylsulfamoyl)phenyl) o,o-dimethyl phosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:35.0%

伐灭磷文献

Development of phage immuno-loop-mediated isothermal amplification assays for organophosphorus pesticides in agro-products.

Anal. Chem. 86(16) , 8441-7, (2014)

Two immuno-loop-mediated isothermal amplification assays (iLAMP) were developed by using a phage-borne peptide that was isolated from a cyclic eight-peptide phage library. One assay was used to screen...

Case histories of bald eagles and other raptors killed by organophosphorus insecticides topically applied to livestock.

J. Wildl. Dis. 23(2) , 292-5, (1987)

Since 1982 when secondary poisoning of a red-tailed hawk (Buteo jamaicensis) was documented following the recommended use of famphur applied topically to cattle, the Patuxent Wildlife Research Center ...

Prediction for the mixture toxicity of six organophosphorus pesticides to the luminescent bacterium Q67.

Ecotoxicol. Environ. Saf. 71(3) , 880-8, (2008)

Organophosphorus (OP) pesticides are ubiquitous in the surface water as mixtures. To examine the mixture toxicity in the multi-component space, the uniform design (UD) which can explore the concentrat...

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伐灭磷