6H-Purin-6-one,2-amino-1,9-dihydro-, 7-oxide

名称

[ CAS 号 ]:
5227-68-9

[ 英文名 ]:
6H-Purin-6-one,2-amino-1,9-dihydro-, 7-oxide

[英文别名 ]:

guanine 7-oxide
2-Amino-3,9-dihydro-6H-purin-6-one 7-oxide
2-Amino-1,9-dihydro-6H-purin-6-one 7-oxide
Antibiotic 3780

物理化学性质

[ 密度 ]:
2.31g/cm3

[ 沸点 ]:
603.8ºC at 760mmHg

[ 分子式 ]:
C₅H₅N₅O₂

[ 分子量 ]:
167.12500

[ 闪点 ]:
319ºC

[ 精确质量 ]:
167.04400

[ PSA ]:
113.28000

[ LogP ]:
0.25540

[ 折射率 ]:
2.046

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8585000

CHEMICAL NAME :: Guanine 7-N-oxide

CAS REGISTRY NUMBER :: 5227-68-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H5-N5-O2

MOLECULAR WEIGHT :: 167.15

WISWESSER LINE NOTATION :: T56 BM DN FVM INJ DO HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,972,1985 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 390 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 27,925,1967

安全信息

[ 海关编码 ]:
2933990090

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海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%