盐酸甲氧安非他明

盐酸甲氧安非他明名称

[ CAS 号 ]:
52740-56-4

[ 中文名 ]:
盐酸甲氧安非他明

[ 英文名 ]:
pma hydrochloride

[英文别名 ]:

dl-4-methoxyamphetaminehydrochloride
P-METHOXYAMPHETAMINE HYDROCHLORIDE

盐酸甲氧安非他明物理化学性质

[ 沸点 ]:
258.2ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₁₆ClNO

[ 分子量 ]:
201.69300

[ 闪点 ]:
11ºC

[ 精确质量 ]:
201.09200

[ PSA ]:
35.25000

[ LogP ]:
3.08720

[ 储存条件 ]:
2-8°C

盐酸甲氧安非他明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH8125000

CHEMICAL NAME :: Phenethylamine, 4-methoxy-alpha-methyl-, hydrochloride, DL-

CAS REGISTRY NUMBER :: 52740-56-4

LAST UPDATED :: 199106

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H15-N-O.Cl-H

MOLECULAR WEIGHT :: 201.72

WISWESSER LINE NOTATION :: ZY1&1R DO1 &GH -DL

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 284 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Vascular - BP elevation not characterized in autonomic section

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,100,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Behavioral - ataxia

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 45,49,1978

盐酸甲氧安非他明安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
Xn,T,F

[ 风险声明 (欧洲) ]:
22-39/23/24/25-23/24/25-11

[ 安全声明 (欧洲) ]:
36/37/39-45-36/37-16

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SH8125000

盐酸甲氧安非他明文献

Studies on distribution and metabolism of para-methoxymethamphetamine (PMMA) in rats after subcutaneous administration.

Toxicology 259(1-2) , 61-8, (2009)

p-Methoxymethamphetamine (PMMA) is an illegal psychedelic drug of abuse derived from an amphetamine structure with a risk to health and reports of several cases of intoxications and fatalities caused ...

The effects of co-administration of 3,4-methylenedioxymethamphetamine ("ecstasy") or para-methoxyamphetamine and moclobemide at elevated ambient temperatures on striatal 5-HT, body temperature and behavior in rats.

Neuroscience 146(1) , 321-9, (2007)

We have recently demonstrated that co-administration of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") with the reversible monoamine oxidase type A (MAO-A) inhibitor moclobemide at an ambient tem...

Effects of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') and para-methoxyamphetamine on striatal 5-HT when co-administered with moclobemide.

Brain Res. 1041(1) , 48-55, (2005)

3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and para-methoxyamphetamine (PMA) are commonly used recreational drugs. PMA, often mistaken for MDMA, is reported to be more toxic in human use than...

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