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5-氯噻吩-2-磺酰胺

5-氯噻吩-2-磺酰胺名称

[ CAS 号 ]:
53595-66-7

[ 中文名 ]:
2-氯噻吩-5-磺酰胺

[ 英文名 ]:
5-Chloro-2-thiophenesulfonamide

[中文别名 ]:

[英文别名 ]:

MFCD00052584
2-Thiophenesulfonamide, 5-chloro-
2-Chloro-5-sulfamoylthiophene
T5SJ BSZW EG
5-Chloro-2-thiophenesulfonamide
5-chlorothiophene-2-sulfonamide

5-氯噻吩-2-磺酰胺物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
366.3±52.0 °C at 760 mmHg

[ 熔点 ]:
113-117 °C(lit.)

[ 分子式 ]:
C₄H₄ClNO₂S₂

[ 分子量 ]:
197.663

[ 闪点 ]:
175.3±30.7 °C

[ 精确质量 ]:
196.937195

[ PSA ]:
96.78000

[ LogP ]:
0.94

[ 外观性状 ]:
白色至淡黄色晶体粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.621

[ 储存条件 ]:
室温

[ 水溶解性 ]:
可溶于：甲醇

5-氯噻吩-2-磺酰胺MSDS

5-氯噻吩-2-磺酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XN0296000

CHEMICAL NAME :: 2-Thiophenesulfonamide, 5-chloro-

CAS REGISTRY NUMBER :: 53595-66-7

BEILSTEIN REFERENCE NO. :: 0130728

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H4-Cl-N-O2-S2

MOLECULAR WEIGHT :: 197.66

WISWESSER LINE NOTATION :: T5SJ BG ESWZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 19,449,1961

5-氯噻吩-2-磺酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S45-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2935009090

5-氯噻吩-2-磺酰胺合成路线

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5-氯噻吩-2-磺酰胺上游产品

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5-氯噻吩-2-磺酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

5-氯噻吩-2-磺酰胺文献

Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.

Bioorg. Med. Chem. Lett. 18(1) , 375-9, (2008)

Bridgehead substituted derivatives of bicyclo[4.2.1]nonanes were synthesized and shown to be potent inhibitors of gamma-secretase. Two related series were synthesized to explore the SARs. More potent ...

Rhodium-catalyzed aerobic N-alkylation of sulfonamides with alcohols. Feng SL, et al.

Chin. Chem. Lett. 22(9) , 1021-1024., (2011)

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