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吡啶-3-羧酸钠

吡啶-3-羧酸钠用途

【用途一】
烟酸的中间体。

吡啶-3-羧酸钠名称

[ CAS 号 ]:
54-86-4

[ 中文名 ]:
烟酸钠

[ 英文名 ]:
sodium nicotinate

[中文别名 ]:

[英文别名 ]:

EINECS 200-215-1
NICOTINIC ACID,SODIUM SALT
3-pyridylcarboxylic acid sodium salt
3-Pyridinecarboxylic acid,sodium salt
pyridine-3-carboxylic acid sodium salt
sodium pyridine-3-carboxylate
Sodium nicotinate
MFCD00064352
Natriumnicotinat

吡啶-3-羧酸钠物理化学性质

[ 密度 ]:
1.293g/cm3

[ 沸点 ]:
292.5ºC at 760mmHg

[ 熔点 ]:
236.6ºC

[ 分子式 ]:
C₆H₄NNaO₂

[ 分子量 ]:
145.09100

[ 闪点 ]:
130.7ºC

[ 精确质量 ]:
145.01400

[ PSA ]:
53.02000

[ 储存条件 ]:
室温

吡啶-3-羧酸钠MSDS

吡啶-3-羧酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2060000

CHEMICAL NAME :: Nicotinic acid, sodium salt

CAS REGISTRY NUMBER :: 54-86-4

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H4-N-O2.Na

MOLECULAR WEIGHT :: 145.10

WISWESSER LINE NOTATION :: T6NJ CVQ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 73,85,1941

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 65,95,1939

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1748,1961 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 9-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral

REFERENCE :: BRBUDU Brain Research Bulletin. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1976- Volume(issue)/page/year: 29,363,1992

吡啶-3-羧酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QT2060000

[ 海关编码 ]:
2933399090

吡啶-3-羧酸钠合成路线

吡啶-3-羧酸钠上下游产品

吡啶-3-羧酸钠上游产品

吡啶-3-羧酸钠下游产品

吡啶-3-羧酸钠制备

【方法一】
可用甲基吡啶经氧化，或用喹啉经氧化（先生成吡啶二羧酸）、脱羧制得。

吡啶-3-羧酸钠海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡啶-3-羧酸钠文献

Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice.

Am. J. Physiol. Endocrinol. Metab. 307(7) , E563-70, (2014)

CL 316,243, a β3-adrenergic agonist, was developed as an antiobesity and diabetes drug and causes rapid decreases in blood glucose levels in mice. The mechanisms mediating this effect have not been fu...

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

J. Nutr. 143(7) , 1046-51, (2013)

In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxyg...

Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B' methyltransferase family in Coffea arabica.

Biochem. Biophys. Res. Commun. 452(4) , 1060-6, (2014)

Trigonelline (N-methylnicotinate), a member of the pyridine alkaloids, accumulates in coffee beans along with caffeine. The biosynthetic pathway of trigonelline is not fully elucidated. While it is qu...

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