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1,2-乙二硫醇

1,2-乙二硫醇用途

【用途一】
用作医药中间体
【用途二】
食品用香料。
【用途三】
用于有机合成和生化研究。用作金属络合剂。

1,2-乙二硫醇名称

[ CAS 号 ]:
540-63-6

[ 中文名 ]:
1,2-乙二硫醇

[ 英文名 ]:
1,2-Ethanedithiol

[中文别名 ]:

[英文别名 ]:

Ethane dithiol
SH2SH
MFCD00004892
ethanedithiol
Ethylene mercaptan
Dithioglycol
ethane-1,2-dithiol
EINECS 208-752-3
1,2-dimercaptoethane
1,2-Ethanedithiol

1,2-乙二硫醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
144.3±13.0 °C at 760 mmHg

[ 熔点 ]:
−41 °C(lit.)

[ 分子式 ]:
C₂H₆S₂

[ 分子量 ]:
94.199

[ 闪点 ]:
44.4±0.0 °C

[ 精确质量 ]:
93.991089

[ PSA ]:
77.60000

[ LogP ]:
1.31

[ 外观性状 ]:
透明无色固体

[ 蒸汽密度 ]:
>1 (vs air)

[ 蒸汽压 ]:
6.5±0.3 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
Store at 0-5°C

[ 稳定性 ]:
Stable. Flammable. Incompatible with oxidizing agents, bases, reducing agents, alkali metals.

[ 水溶解性 ]:
insoluble

1,2-乙二硫醇MSDS

1,2-乙二硫醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI3325000

CHEMICAL NAME :: 1,2-Ethanedithiol

CAS REGISTRY NUMBER :: 540-63-6

BEILSTEIN REFERENCE NO. :: 0505946

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C2-H6-S2

MOLECULAR WEIGHT :: 94.20

WISWESSER LINE NOTATION :: SH2SH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 342 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,249,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 17,235,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02101

1,2-乙二硫醇安全信息

[ 符号 ]:

GHS02, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H301-H310 + H330-H319

[ 警示性声明 ]:
P260-P280-P284-P301 + P310-P302 + P350-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R10;R21;R23/25

[ 安全声明 (欧洲) ]:
S36/37/39-S45-S26-S16-S36/37

[ 危险品运输编码 ]:
UN 3071 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
KI3325000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
29309070

1,2-乙二硫醇合成路线

1,2-乙二硫醇上下游产品

1,2-乙二硫醇上游产品

1,2-乙二硫醇下游产品

1,2-乙二硫醇制备

1.先由二溴乙烷与硫脲合成二异硫脲乙烷溴化物，再经氢氧化钠、硫酸处理得到1,2-二巯基乙烷。

2.将硫脲和95%的乙醇加热回流至清亮，停止加热，不断搅拌下，慢慢加入二溴乙烷（二溴乙烷用量为硫脲物质量的1／2）。2h后反应结束，将析出的结晶在搅拌下加到25%～30%的氢氧化钠溶液中，回流反应6h，换上蒸馏装置，慢慢加入稀硫酸溶液至反应物对刚果红试纸呈酸性，再多加20%的酸，加完后，进行水蒸气蒸馏，静置分层，分出油层，水层用乙醚萃取，回收的乙醚层与油层合并，用无水氯化钙干
燥后减压蒸馏，收集2.67MPa下60～145℃的馏分，再进行常压蒸馏，收集148～150℃馏分，即为成品。
过程反应式为：

1,2-乙二硫醇海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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