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依托孕烯

依托孕烯用途

Etonogestrel是甾体类孕酮。

依托孕烯名称

[ CAS 号 ]:
54048-10-1

[ 中文名 ]:
依托孕烯

[ 英文名 ]:
Etonogestrel

[中文别名 ]:

[英文别名 ]:

EINECS 258-936-2
Etonoestrel
3-Keto-desogestrel 3-Oxo-desogestrel
3-Oxodesogestrel
3-Keto-Org 2969
3-keto-desogestrel
3-Ketodesogestrel
Etonogestrel
Nexplanon
UNII-304GTH6RNH

依托孕烯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
473.1±45.0 °C at 760 mmHg

[ 熔点 ]:
182-184ºC

[ 分子式 ]:
C₂₂H₂₈O₂

[ 分子量 ]:
324.457

[ 闪点 ]:
201.1±21.3 °C

[ 精确质量 ]:
324.208923

[ PSA ]:
37.30000

[ LogP ]:
4.22

[ 外观性状 ]:
白色或近乎于白色结晶粉末

[ 蒸汽压 ]:
0.0±2.7 mmHg at 25°C

[ 折射率 ]:
1.575

[ 储存条件 ]:
-20°C

依托孕烯MSDS

依托孕烯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JF8290000

CHEMICAL NAME :: 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-11-methylene-, (17-alpha)-

CAS REGISTRY NUMBER :: 54048-10-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H28-O2

MOLECULAR WEIGHT :: 324.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10500 ng/kg

SEX/DURATION :: female 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 17,19,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 50 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985

依托孕烯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H351-H360

[ 警示性声明 ]:
P201-P280-P308 + P313

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
60-40

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
JF8290000

依托孕烯合成路线

依托孕烯上下游产品

依托孕烯上游产品

依托孕烯下游产品

依托孕烯文献

Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs.

Contraception 90(2) , 123-9, (2014)

The potential effect of hormonal contraception on HIV-1 acquisition and transmission represents an important public health issue. Several observational studies have suggested an association between th...

Newer non-oral hormonal contraception.

BMJ 346 , f341, (2013)

The combined etonogestrel/ethinyl estradiol contraceptive vaginal ring.

Expert Opin. Pharmacother. 8(11) , 1769-77, (2007)

Many factors influence the effectiveness of contraceptive methods. Oral contraceptives are the second most popular contraceptive method after female sterilization in the US. A total of 25% of women do...

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