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3-(二乙氨基)-2,2-二甲基-1-丙醇1-(4-氨基苯甲酸酯)盐酸盐

用途

Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse.

名称

[ CAS 号 ]:
553-63-9

[ 中文名 ]:
3-(二乙氨基)-2,2-二甲基-1-丙醇1-(4-氨基苯甲酸酯)盐酸盐

[ 英文名 ]:
Dimethocaine hydrochloride

[中文别名 ]:

盐酸拉罗卡因

[英文别名 ]:

Larocaine HCl
Dimethocaine HCl

物理化学性质

[ 密度 ]:
1.035g/cm3

[ 沸点 ]:
403.5ºC at 760 mmHg

[ 熔点 ]:
196-197ºC

[ 分子式 ]:
C₁₆H₂₇ClN₂O₂

[ 分子量 ]:
314.851

[ 闪点 ]:
197.8ºC

[ 精确质量 ]:
314.176117

[ PSA ]:
55.56000

[ LogP ]:
4.17680

[ 储存条件 ]:
-20°C，密闭，干燥

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB1580000

CHEMICAL NAME :: 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, p-aminobenzoate, hydrochloride

CAS REGISTRY NUMBER :: 553-63-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H26-N2-O2.Cl-H

MOLECULAR WEIGHT :: 314.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,508,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: WDMU** "Vergleichend-pharmakologische Untersuchungen ueber die haemolytische Wirkung und die Toxizitat der Lokalanaesthetika, Dissertation," Walther, M., Pharmakologischen Instit Martin Luther-Universitat Halle-Wittenburg, Ger. Dem. Rep., 1936 Volume(issue)/page/year: -,-,1936

安全信息

[ 海关编码 ]:
2922499990

海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%