锥虫胂胺
锥虫胂胺名称
[ CAS 号 ]:
554-72-3
[ 中文名 ]:
锥虫胂胺
[ 英文名 ]:
Arsonic acid,As-[4-[(2-amino-2-oxoethyl)amino]phenyl]-, sodium salt (1:1)
[英文别名 ]:
- Monosodium N-(carbamoylmethyl)arsanilate
- Trypothane
- (4-(2-AMINO-2-OXOETHYL)AMINO)-PHENYL)ARSONICACID
- Tryponersyl
- Tryparsone
- Novatoxyl
- Glyphenarsine
- Monosodium N-phenylglycinamide-p-arsonate
锥虫胂胺物理化学性质
[ 沸点 ]:
687ºC at 760mmHg
[ 分子式 ]:
C8H10AsN2NaO4
[ 分子量 ]:
296.08700
[ 闪点 ]:
369.3ºC
[ 精确质量 ]:
295.97500
[ PSA ]:
115.48000
锥虫胂胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CF9480000
- CHEMICAL NAME :
- Arsanilic acid, N-(carbamoylmethyl)-, monosodium salt
- CAS REGISTRY NUMBER :
- 554-72-3
- LAST UPDATED :
- 198809
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C8-H10-As-N2-O4.Na
- MOLECULAR WEIGHT :
- 296.11
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 68,944,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 2,28,1947
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 29,125,1931
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 29,125,1931
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 23,107,1924
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 29,125,1931
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