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对氨基苯甲酸钠

对氨基苯甲酸钠用途

生化研究。有机合成。

对氨基苯甲酸钠名称

[ CAS 号 ]:
555-06-6

[ 中文名 ]:
4-氨基苯甲酸钠

[ 英文名 ]:
Sodium 4-aminobenzoate

[中文别名 ]:

[英文别名 ]:

MFCD00064395
Benzoic acid, 4-amino-, sodium salt (1:1)
4-aminobenzoic acid sodium salt
Sodium 4-aminobenzoate
EINECS 209-080-3

对氨基苯甲酸钠物理化学性质

[ 沸点 ]:
339.9ºCat 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₇H₆NNaO₂

[ 分子量 ]:
159.118

[ 闪点 ]:
159.4ºC

[ 精确质量 ]:
159.029617

[ PSA ]:
66.15000

[ LogP ]:
0.21350

[ 外观性状 ]:
米色结晶粉末

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开储运

[ 水溶解性 ]:
水溶性：可溶

对氨基苯甲酸钠MSDS

对氨基苯甲酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2975000

CHEMICAL NAME :: Benzoic acid, p-amino-, monosodium salt

CAS REGISTRY NUMBER :: 555-06-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H6-N-O2.Na

MOLECULAR WEIGHT :: 159.13

WISWESSER LINE NOTATION :: ZR DVO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2760 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 49,184,1942

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 146,466,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2840 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MECHAN Medicinal Chemistry, A Series of Reviews. (New York, NY) V.1-6, 1951-63. Discontinued. Volume(issue)/page/year: 6,343,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84702 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

对氨基苯甲酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
DG2975000

[ 海关编码 ]:
2922499990

对氨基苯甲酸钠合成路线

对氨基苯甲酸钠制备

苯胺磺化、转位而得：工艺过程如下：1.转位（磺化反应）在转鼓反应器内加入450kg98%硫酸。转鼓转动后于1h内加入苯胺（99%）400kg。将炉温升至160℃，开启喷射泵使系统的真空度在53.3kPa以上。炉温再升至200℃，保温0.5h。继续升温至260℃，保温至转位完成。以视镜出现黑粉、铁球发出响声为终点，降温，关闭喷射泵，回转10min。排风，冷至80℃，加入2500L水，转动混合，放入地槽。2.中和在地槽中，物料升温至70-80℃，加入碳酸钠（约230kg）中和至pH=7-7.5。移入到已有600L母液的中和锅中，调整相对密度至1.12左右。加热至沸，加入活性炭4kg，搅拌0.5h。热过滤，滤渣用热水洗涤；滤液蒸浓到相对密度约1.18。放入结晶桶，以8h冷却至30℃。离心过滤，滤液作下批母液；滤饼为对氨基磺酸钠（850kg左右）。总收率86.5%。产品规格：HG2---372--80。外观为粉红色或浅玫瑰色结晶，含量≥97.0%。原料消耗定额：苯胺（99%）460kg/t、纯碱（98%）264kg/t、硫酸（98%）492kg/t。

对氨基苯甲酸钠海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

对氨基苯甲酸钠文献

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Eur. J. Pharm. Biopharm. 88(2) , 351-60, (2014)

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Determination of ultraviolet filters in bathing waters by stir bar sorptive-dispersive microextraction coupled to thermal desorption-gas chromatography-mass spectrometry.

Talanta 147 , 246-52, (2015)

In this work, a new approach that combines the advantages of stir bar sorptive extraction (SBSE) and dispersive solid phase extraction (DSPE), i.e. stir bar sorptive-dispersive microextraction (SBSDµE...

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