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DL-甲基多巴

DL-甲基多巴名称

[ CAS 号 ]:
555-29-3

[ 中文名 ]:
DL-甲基多巴

[ 英文名 ]:
3-Hydroxy-alpha-methyl-DL-tyrosine

[中文别名 ]:

[英文别名 ]:

a-Methyl-L-dopa
α-Methyl-L-dopa
Dopegyt
EINECS 209-088-7
3-(3,4-Dihydroxyphenyl)-2-methyl alanine
L-(-)-b-(3,4-Dihydroxyphenyl)-a-methylalanine
L-(-)-α-Methyl-β-(3,4-dihydroxyphenyl)alanine
L-(-)-a-Methyl-b-(3,4-dihydroxyphenyl)alanine
rac Alpha-Methyl DOPA
2-Methyl-3-(3,4-dihydroxyphenyl)-DL-alanine

DL-甲基多巴物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
441.6±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₃NO₄

[ 分子量 ]:
211.214

[ 闪点 ]:
220.9±28.7 °C

[ 精确质量 ]:
211.084457

[ PSA ]:
103.78000

[ LogP ]:
0.13

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.635

[ 储存条件 ]:
−20°C

DL-甲基多巴毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AY5940000

CHEMICAL NAME :: Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DL-

CAS REGISTRY NUMBER :: 555-29-3

LAST UPDATED :: 199403

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H13-N-O4

MOLECULAR WEIGHT :: 211.24

WISWESSER LINE NOTATION :: QVXZ1&1R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1317 mg/kg

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1318,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989

DL-甲基多巴安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36

[ 安全声明 (欧洲) ]:
26-36/37

[ WGK德国 ]:
3