S-(2-氨乙基)异硫脲溴鎓氢溴酸盐

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐用途

【用途一】
用于有机合成，酶激活剂，辐射病预防，游离基的解毒剂。该品作为药物能促进脑细胞代谢，增加对碳水化合物的利用，提高中枢兴奋性。能使外伤性昏迷病人迅速地恢复脑的功能，并有对抗中枢抑制药物的作用。适用于外伤性昏迷、心血管疾患所致的昏迷、一氧化碳中毒、巴比妥类及安定药物的中毒、放射性损伤及脑缺氧等。

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐名称

[ CAS 号 ]:
56-10-0

[ 中文名 ]:
乙胺硫脲

[ 英文名 ]:
S-(2-Aminoethyl)pseudothiourea dihydrobromide

[中文别名 ]:

[英文别名 ]:

b-aminoethylisothiuronium bromide hydrobromide
2-(β-Aminoethyl)isothiuronium bromide hydrobromide
S-(β-Aminoethyl)isothiuronium bromide hydrobromide
S-(2-Aminoethyl)isothiuronium bromide hydrobromide
2-Aminoethyl carbamimidothioate dihydrobromide
2-AMINOETHYLISO-THIOURONIUM BROMIDE
surrectan
AET,DiHBr
AET,DIHYDROBROMIDE
2-Aminoethylisothiouronium bromide hydrochloride

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐物理化学性质

[ 沸点 ]:
231.1ºC at 760mmHg

[ 熔点 ]:
190-196 °C(lit.)

[ 分子式 ]:
C₃H₁₁Br₂N₃S

[ 分子量 ]:
281.013

[ 闪点 ]:
93.6ºC

[ 精确质量 ]:
278.904022

[ PSA ]:
101.19000

[ LogP ]:
2.98830

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：可溶

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐MSDS

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM0175000

CHEMICAL NAME :: Pseudourea, (2-aminoethyl)-2-thio-, dihydrobromide

CAS REGISTRY NUMBER :: 56-10-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C3-H9-N3-S.2Br-H

MOLECULAR WEIGHT :: 281.05

WISWESSER LINE NOTATION :: Z2SYZUM &EH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 288 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 815 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 242 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85400 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 236 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 356 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5474 mg/kg/40D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 415 mg/kg/15D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 334,317,1995

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UM0175000

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐合成路线

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐上下游产品

S-(2-氨乙基)异硫脲溴鎓氢溴酸盐上游产品

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S-(2-氨乙基)异硫脲溴鎓氢溴酸盐制备

（1）由氨基乙醇溴化得到溴乙胺氢溴酸盐后，与硫脲缩合而得：溴化：在反应罐中投入氢溴酸，冷却后，搅拌下滴加氨基乙醇，于30min内滴加完毕，然后蒸出投入量85%的氢溴酸，约20h蒸完。浓缩液冷却至70-80℃后将其放入预先冷冻的丙酮中，再冷却至5℃以下结晶，过滤，用冷丙酮洗涤，干燥，得溴乙胺氢溴酸盐。熔点165℃。缩合：将异丙醇和硫脲混合搅拌，加热至70℃，迅速加入溴乙胺氢溴酸盐，内温升至82℃，反应40min。冷至10℃以下过滤，用冷异丙醇洗涤，再用少量乙酸乙酯洗涤，干燥，得克脑迷粗品。在粗品中加入4.75倍甲醇（V/V），0.02倍活性炭，搅拌加热回流15-20min。趁热过滤，冷却，半小时后加入粗品量的4.28倍乙醚（V/V）。继续冷却，待结晶完全后过滤，干燥，得成品。总收率56-58%（对氨基乙醇计）。（2）以环乙胺、氢溴酸、硫脲为原料合成：先将硫脲与溴氢酸混合，在150℃以下滴加环乙胺，待反应完成后，加入活性炭过滤，然后减压脱水，温度在50℃以下即析出结晶，过滤，以无水乙醇洗两次，即得成品。

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