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N-甲基-beta-苯乙胺

N-甲基-beta-苯乙胺名称

[ CAS 号 ]:
589-08-2

[ 中文名 ]:
n-甲基苯基乙胺

[ 英文名 ]:
N-Methylphenethylamine

[中文别名 ]:

[英文别名 ]:

N-Methyl-2-phenylethanamine
MFCD00008291
N-Methylphenethylamine
N-Methyl-β-phenylethylamine
EINECS 209-632-3
Benzeneethanamine, N-methyl-
α-Phenyl-β-methylaminoethane

N-甲基-beta-苯乙胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
201.7±9.0 °C at 760 mmHg

[ 熔点 ]:
0.93ºC

[ 分子式 ]:
C₉H₁₃N

[ 分子量 ]:
135.206

[ 闪点 ]:
73.9±0.0 °C

[ 精确质量 ]:
135.104797

[ PSA ]:
12.03000

[ LogP ]:
1.60

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.509

[ 储存条件 ]:
室温，干燥

N-甲基-beta-苯乙胺MSDS

N-甲基-beta-苯乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH9625000

CHEMICAL NAME :: Phenethylamine, N-methyl-

CAS REGISTRY NUMBER :: 589-08-2

BEILSTEIN REFERENCE NO. :: 0636347

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N

MOLECULAR WEIGHT :: 135.23

WISWESSER LINE NOTATION :: 1M2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,341,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 195,647,1940 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 126 mg/kg

SEX/DURATION :: female 5 day(s) pre-mating female 1-37 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 69(Suppl 1),387,1991 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

N-甲基-beta-苯乙胺安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61-S39

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
SH9625000

[ 海关编码 ]:
2921499090

N-甲基-beta-苯乙胺合成路线

N-甲基-beta-苯乙胺上下游产品

N-甲基-beta-苯乙胺上游产品

N-甲基-beta-苯乙胺下游产品

N-甲基-beta-苯乙胺海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-甲基-beta-苯乙胺文献

Structure–activity correlations for β-phenethylamines at human trace amine receptor 1

Bioorg. Med. Chem. 16 , 7415-23, (2008)

CoMFA 3D-QSAR studies on the potency of 68 β-phenethylamine analogs to activate hTAAR 1 (61% steric, 39% electrostatic) indicates that bulk both at nitrogen and 4-aryl leads to lower potency.

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction-liquid chromatography-mass spectrometry with positive-ion electrospray ionization.

J. Chromatogr. A. 1232 , 19-26, (2012)

The analysis of cellular metabolic processes is of fundamental biological interest. Cellular metabolites, such as the intermediates of the tricarboxylic acid (TCA) cycle, provide essential information...

A rapid, sensitive electron-capture gas chromatographic procedure for analysis of metabolites of N-methyl,N-propargylphenylethylamine, a potential neuroprotective agent.

J. Pharmacol. Toxicol. Methods 52(3) , 373-8, (2005)

N-Methyl,N-propargyphenylethylamine (MPPE) is a novel analog of (-)-deprenyl, a drug prescribed for Parkinson's disease and shown to have neuroprotective and neurorescue properties in a wide variety o...

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