马来酸咪达唑仑

马来酸咪达唑仑用途

【用途一】
用于安眠，也可用于焦虑、不安、松驰肌肉及抗惊厥等。

马来酸咪达唑仑名称

[ CAS 号 ]:
59467-94-6

[ 中文名 ]:
马来酸咪达唑仑

[ 英文名 ]:
midazolam maleate

[中文别名 ]:

[英文别名 ]:

Midazolam maleate salt
Dormicum
midazolam maleate
Ro 21-3981/001
MFCD00941440
EINECS 261-775-0
Ro-21-3981/001
Dormicum maleate
Hypnovel

马来酸咪达唑仑物理化学性质

[ 沸点 ]:
496.9ºC at 760 mmHg

[ 分子式 ]:
C₂₂H₁₇ClFN₃O₄

[ 分子量 ]:
441.840

[ 精确质量 ]:
441.089172

[ PSA ]:
104.78000

[ LogP ]:
3.47160

[ 储存条件 ]:
2-8°C

马来酸咪达唑仑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2922200

CAS REGISTRY NUMBER :: 59467-94-6

LAST UPDATED :: 199707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H13-Cl-F-N3.C4-H4-O4

MOLECULAR WEIGHT :: 441.87

WISWESSER LINE NOTATION :: T B576 BN DN HN GHJ C1 IR BF& LG &QV1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2180,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 86 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,2180,1981

马来酸咪达唑仑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
NI2922200

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

马来酸咪达唑仑上下游产品

马来酸咪达唑仑上游产品

马来酸咪达唑仑下游产品

马来酸咪达唑仑文献

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin.

PLoS ONE 5 , e12477, (2010)

The innate immune system is of vital importance for protection against infectious pathogens. Inflammasome mediated caspase-1 activation and subsequent release of pro-inflammatory cytokines like IL-1be...

Midazolam produces vasodilation by mixed endothelium-dependent and -independent mechanisms.

Anesth. Analg. 78 , 710, (1994)

Aortic rings were obtained from rat thoracic aorta and studied in vitro with and without functionally intact endothelium to determine whether "the mechanism" requires endothelium [or endothelium-deriv...

Opposite effects of midazolam and beta-carboline-3-carboxylate ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo microdialysis.

Eur. J. Pharmacol. 261 , 65, (1994)

This report describes the effects of midazolam and beta-carboline-3-carboxylate ethyl ester (beta-CCE) on extracellular concentrations of dopamine in the nucleus accumbens of freely moving rats measur...

更多文献