依莫司汀
依莫司汀名称
[ CAS 号 ]:
60784-46-5
[ 中文名 ]:
依莫司汀
[ 英文名 ]:
elmustine
[英文别名 ]:
- Hydroxyethyl CNU
- CNU-ethanol
- Hecnu
- Elmustine
- Elmustine [INN]
- Elmustinum [Latin]
- Elmustina [Spanish]
依莫司汀物理化学性质
[ 密度 ]:
1.45g/cm3
[ 熔点 ]:
56°C
[ 分子式 ]:
C5H10ClN3O3
[ 分子量 ]:
195.60400
[ 精确质量 ]:
195.04100
[ PSA ]:
82.00000
[ LogP ]:
0.30140
[ 折射率 ]:
1.549
[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放
依莫司汀毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YS4986000
- CHEMICAL NAME :
- Urea, 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitroso-
- CAS REGISTRY NUMBER :
- 60784-46-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C5-H10-Cl-N3-O3
- MOLECULAR WEIGHT :
- 195.63
- WISWESSER LINE NOTATION :
- Q2MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25300 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - ulceration or bleeding from stomach Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 16 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Brain and Coverings - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 64 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 96 mg/kg/60W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- DNA damage
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - mouse Lung
- DOSE/DURATION :
- 1 mg/L/1H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 44,87,1977
依莫司汀合成路线
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