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2-亚硝基甲苯

2-亚硝基甲苯用途

用于有机合成。

2-亚硝基甲苯名称

[ CAS 号 ]:
611-23-4

[ 中文名 ]:
厄多司坦

[ 英文名 ]:
1-Methyl-2-nitrosobenzene

[中文别名 ]:

[英文别名 ]:

2-Methyl-1-nitrosobenzene
o-Nitrosotoluene
1-Methyl-2-nitrosobenzene
Benzene,1-methyl-2-nitroso
Benzene, 1-methyl-2-nitroso-
MFCD00002061
2-methyl-nitrosobenzene
TOLUENE,o-NITROSO
2-nitrosotoluene
ortho-nitrosotoluene

2-亚硝基甲苯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
199.9±19.0 °C at 760 mmHg

[ 熔点 ]:
72-75 °C(lit.)

[ 分子式 ]:
C₇H₇NO

[ 分子量 ]:
121.137

[ 闪点 ]:
74.7±26.8 °C

[ 精确质量 ]:
121.052765

[ PSA ]:
29.43000

[ LogP ]:
2.47

[ 外观性状 ]:
无色固体

[ 蒸汽压 ]:
0.5±0.4 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
0-6°C

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents.

2-亚硝基甲苯MSDS

2-亚硝基甲苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT3400000

CHEMICAL NAME :: Toluene, o-nitroso-

CAS REGISTRY NUMBER :: 611-23-4

BEILSTEIN REFERENCE NO. :: 1927295

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: ONR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 103 gm/kg/73W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 umol/plate

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,618,1987

2-亚硝基甲苯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H315-H319-H332-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN1759

[ WGK德国 ]:
3

[ RTECS号 ]:
XT3400000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

2-亚硝基甲苯合成路线

2-亚硝基甲苯文献

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.

Arch. Biochem. Biophys. 436(2) , 265-75, (2005)

The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring l...

Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine.

Arch. Biochem. Biophys. 372(1) , 97-106, (1999)

Mechanisms of DNA damage by metabolites of carcinogenic o-toluidine in the presence of metals were investigated by the DNA sequencing technique using (32)P-labeled human DNA fragments. 4-Amino-3-methy...

Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.

Cancer Lett. 16(1) , 103-8, (1982)

o-Toluidine hydrochloride and one of its metabolites, o-nitrosotoluene, were administered in the diet (0.028 mol/kg diet) to 2 groups of 30 male F-344 rats for 72 weeks. o-Nitrosotoluene induced signi...

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