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2-苄氧基乙醇

2-苄氧基乙醇用途

2-(Benzyloxy)ethanol 是一种 PROTAC linker,属于 PEG 类。2-(Benzyloxy)ethanol 可用于合成 PROTAC 分子。

2-苄氧基乙醇名称

[ CAS 号 ]:
622-08-2

[ 中文名 ]:
2-苄氧基乙醇

[ 英文名 ]:
2-(Benzyloxy)ethanol

[中文别名 ]:

[英文别名 ]:

2-(Benzyloxy)ethanol
Ethanol, 2- (benzyloxy)-
2-(Benzyl-Oxy)Ethan-1-Ol
MFCD00002868
2-phenylmethoxyethanol
Benzyl cellosolve
Ethanol, 2-(phenylmethoxy)-
Glycol benzyl ether
UNII-06S8147L47
EINECS 210-719-3

2-苄氧基乙醇生物活性

[ 描述 ]:

2-(Benzyloxy)ethanol 是一种 PROTAC linker,属于 PEG 类。2-(Benzyloxy)ethanol 可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. Reed NN, et al. A one-step synthesis of monoprotected polyethylene glycol ethers. J Org Chem. 2000 Sep 8;65(18):5843-5.

2-苄氧基乙醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
254.4±15.0 °C at 760 mmHg

[ 熔点 ]:
<-75ºC

[ 分子式 ]:
C₉H₁₂O₂

[ 分子量 ]:
152.190

[ 闪点 ]:
108.0±14.6 °C

[ 精确质量 ]:
152.083725

[ PSA ]:
29.46000

[ LogP ]:
1.38

[ 外观性状 ]:
无色至淡黄色液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶；可溶于：乙醚,醇

2-苄氧基乙醇MSDS

2-苄氧基乙醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ7550000

CHEMICAL NAME :: Ethanol, 2-(benzyloxy)-

CAS REGISTRY NUMBER :: 622-08-2

BEILSTEIN REFERENCE NO. :: 2043566

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H12-O2

MOLECULAR WEIGHT :: 152.21

WISWESSER LINE NOTATION :: Q2O1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

2-苄氧基乙醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KJ7550000

[ 海关编码 ]:
2909499000

2-苄氧基乙醇合成路线

2-苄氧基乙醇上下游产品

2-苄氧基乙醇上游产品

2-苄氧基乙醇下游产品

2-苄氧基乙醇制备

精制方法：分馏。

2-苄氧基乙醇海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

2-苄氧基乙醇文献

Alkylation of active methylene compounds with alcohols catalyzed by an iridium complex.

Chem. Commun. (Camb.) , 2850, (2007)

Base-free catalytic alpha-alkylation of active methylene compounds with primary alcohols was successfully achieved using an [IrCl(cod)](2) complex in the presence of PPh(3) to afford the corresponding...

A structure-based library approach to kinase inhibitors. Norman TC, et al.

J. Am. Chem. Soc. 118(31) , 7430-31, (1996)

Poly (benzyloxy ethyl methacrylate): preparation by free radical polymerization and by group transfer polymerization; with subsequent debenzylation to form poly (2-hydroxyethyl methacrylate). Dyakonov TA, et al.

Eur. Polymer J. 36(9) , 1779-93, (2000)

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