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巴豆酸甲酯

巴豆酸甲酯用途

【用途一】
用作有机合成中间体和香料。

巴豆酸甲酯名称

[ CAS 号 ]:
623-43-8

[ 中文名 ]:
巴豆酸甲酯

[ 英文名 ]:
Methyl (2E)-2-butenoate

[中文别名 ]:

[英文别名 ]:

Methyl-(2E)-but-2-enoat
methyl-trans-3-triethylsilylacrylate
methyl trans-crotonate
Crotonic acid, methyl ester
EINECS 210-793-7
Methyl (2E)-but-2-enoate
Methyl Crotonate
methyl-trans-4-oxo-2-pentoate
E-1-triethylsilylpropensaeuremethylester
2-Butenoic acid, methyl ester

巴豆酸甲酯物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
121.0±0.0 °C at 760 mmHg

[ 分子式 ]:
C₅H₈O₂

[ 分子量 ]:
100.116

[ 闪点 ]:
4.4±0.0 °C

[ 精确质量 ]:
100.052429

[ PSA ]:
26.30000

[ LogP ]:
1.32

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
14.9±0.2 mmHg at 25°C

[ 折射率 ]:
1.414

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
IMMISCIBLE

巴豆酸甲酯MSDS

巴豆酸甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GQ5710000

CHEMICAL NAME :: Crotonic acid, methyl ester, (E)-

CAS REGISTRY NUMBER :: 623-43-8

BEILSTEIN REFERENCE NO. :: 1720292

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C5-H8-O2

MOLECULAR WEIGHT :: 100.13

WISWESSER LINE NOTATION :: 2U1VO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >19000 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 10 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979

巴豆酸甲酯安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;Xi:Irritant;

[ 风险声明 (欧洲) ]:
R11;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S36-S33-S9

[ 危险品运输编码 ]:
UN 3272 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
GQ5710000

[ 包装等级 ]:
II

[ 危险类别 ]:
3.0

[ 海关编码 ]:
29161980

巴豆酸甲酯合成路线

巴豆酸甲酯上下游产品

巴豆酸甲酯上游产品

巴豆酸甲酯下游产品

巴豆酸甲酯制备

1.由巴豆酸与甲醇经酯化而得。将800g巴豆酸、1L甲醇、130g硫酸、300ml四氯化碳配成的反应液在水浴上加热，脱水酯化后回收四氯化碳，得到粗品巴豆酸甲酯。然后用水洗去粗品中未反应的巴豆酸，再用5%碳酸钠洗涤，用减压蒸馏精制而得成品。

巴豆酸甲酯海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

巴豆酸甲酯文献

First total syntheses of the phytotoxins solanapyrones D and E via the domino Michael protocol.

J. Org. Chem. 67(17) , 5969-76, (2002)

The phytotoxins solanapyrones D (1) and E (2) have been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl cro...

The vinylogous aldol reaction of unsaturated esters and enolizable aldehydes using the novel Lewis acid aluminum tris(2,6-di-2-naphthylphenoxide).

Org. Lett. 14(11) , 2678-81, (2012)

The synthesis of the novel Lewis acid, aluminum tris(2,6-di-2-naphthylphenoxide) (ATNP), and its use in the vinylogous aldol reaction between methyl crotonate and enolizable aldehydes are described. A...

Solvent engineering: an effective tool to direct chemoselectivity in a lipase-catalyzed Michael addition. Priego J, et al.

Tetrahedron 65(2) , 536-539, (2009)

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