<生产厂家价格>

甘油-1,1,2,3,3-d5

甘油-1,1,2,3,3-d5用途

甘油-d5是氘标记的甘油[1]。甘油用于聚丙烯酰胺凝胶电泳的样品制备和凝胶形成[2][3][4]。

甘油-1,1,2,3,3-d5名称

[ CAS 号 ]:
62502-71-0

[ 中文名 ]:
甘油-1,1,2,3,3-d5

[ 英文名 ]:
Glycerol-d5

[中文别名 ]:

甘油-D5

[英文别名 ]:

1,1,2,3,3-D5-glycerol
Bulbold-d5
Osmoglyn-d5
1,1,2,3,3-pentadeuterio-propane-1,2,3-triol
Glycerin-d5
MFCD00084148
Glyceritol-d5
Propanetriol-d5
Glysanin-d5
Glycerol-1,1,2,3,3-d5

甘油-1,1,2,3,3-d5生物活性

[ 描述 ]:

甘油-d5是氘标记的甘油[1]。甘油用于聚丙烯酰胺凝胶电泳的样品制备和凝胶形成[2][3][4]。

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Pennings S, et al. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strengthpolyacrylamide gel electrophoresis. Nucleic Acids Res. 1992 Dec 25;20(24):6667-72.

[3]. Yazdani SS, et al. Anaerobic fermentation of glycerol: a path to economic viability for the biofuelsindustry. Curr Opin Biotechnol. 2007 Jun18(3):213-9.

[4]. Huang ZH, et al. Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure. Eur J Pharmacol. 2000 Oct 20406(3):453-60.

甘油-1,1,2,3,3-d5物理化学性质

[ 密度 ]:
1.331 g/mL at 25ºC

[ 沸点 ]:
182ºC(lit.)

[ 熔点 ]:
20ºC(lit.)

[ 分子式 ]:
C₃H₃D₅O₃

[ 分子量 ]:
97.12460

[ 闪点 ]:
320 °F

[ 精确质量 ]:
97.07870

[ PSA ]:
60.69000

[ 外观性状 ]:
无色液体

[ 折射率 ]:
n20/D 1.472(lit.)

[ 储存条件 ]:
2-8°C

甘油-1,1,2,3,3-d5MSDS

甘油-1,1,2,3,3-d5安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

甘油-1,1,2,3,3-d5合成路线

甘油-1,1,2,3,3-d5上下游产品

甘油-1,1,2,3,3-d5上游产品

甘油-1,1,2,3,3-d5下游产品

甘油-1,1,2,3,3-d5文献

Anomalously large isotope effect in the glass transition of water.

Proc. Natl. Acad. Sci. U. S. A. 111(49) , 17402-7, (2014)

We present the discovery of an unusually large isotope effect in the structural relaxation and the glass transition temperature Tg of water. Dielectric relaxation spectroscopy of low-density as well a...

Production and characterization of recombinant perdeuterated cholesterol oxidase.

Anal. Biochem. 485 , 102-8, (2015)

Cholesterol oxidase (CO) is a FAD (flavin adenine dinucleotide) containing enzyme that catalyzes the oxidization and isomerization of cholesterol. Studies directed toward elucidating the catalytic mec...

Quantitative 3D molecular cutaneous absorption in human skin using label free nonlinear microscopy.

J. Control. Release 200 , 78-86, (2015)

Understanding the penetration mechanisms of drugs into human skin is a key issue in pharmaceutical and cosmetics research. To date, the techniques available for percutaneous penetration of compounds f...

更多文献