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4-氯-3-硝基苯胺

4-氯-3-硝基苯胺名称

[ CAS 号 ]:
635-22-3

[ 中文名 ]:
3-硝基-4-氯苯胺

[ 英文名 ]:
4-Chloro-3-nitroaniline

[中文别名 ]:

[英文别名 ]:

4-Chloro-3-nitrobenzenamine
Aniline,4-chloro-3-nitro
1-amino-3-nitro-4-chlorobenzene
2-nitro-4-amino chlorobenzene
4-Amino-1-chloro-2-nitrobenzene
MFCD00007844
4'-chloro-3'-nitroaniline
3-NITRO-4-CHLOROANILINE
EINECS 211-231-3
4-chloro-3-nitro-phenylamine

4-氯-3-硝基苯胺物理化学性质

[ 密度 ]:
1.494 g/cm3

[ 沸点 ]:
344.5ºC at 760 mmHg

[ 熔点 ]:
99-101 °C(lit.)

[ 分子式 ]:
C₆H₅ClN₂O₂

[ 分子量 ]:
172.56900

[ 闪点 ]:
162.2ºC

[ 精确质量 ]:
172.00400

[ PSA ]:
71.84000

[ LogP ]:
2.93480

[ 外观性状 ]:
赭色粉末

[ 折射率 ]:
1.646

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

4-氯-3-硝基苯胺MSDS

4-氯-3-硝基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1750000

CHEMICAL NAME :: Aniline, 4-chloro-3-nitro-

CAS REGISTRY NUMBER :: 635-22-3

BEILSTEIN REFERENCE NO. :: 1309394

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR DG CNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5850 mg/kg/90D-I

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - other hemolysis with or without anemia Related to Chronic Data - changes in testicular weight

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,551,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9772 mg/kg/14D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0882-0452 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5850 mg/kg

SEX/DURATION :: male 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,551,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993

4-氯-3-硝基苯胺安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330-H373-H411

[ 警示性声明 ]:
P260-P264-P273-P280-P284-P302 + P350

[ 危害码 (欧洲) ]:
T+:Verytoxic;N:Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R26/27/28;R33;R51/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S61-S28A

[ 危险品运输编码 ]:
UN 2237 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BX1750000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214210

4-氯-3-硝基苯胺合成路线

4-氯-3-硝基苯胺上下游产品

4-氯-3-硝基苯胺上游产品

4-氯-3-硝基苯胺下游产品

4-氯-3-硝基苯胺海关

[ 海关编码 ]: 2921420090

[ 中文概述 ]:
2921420090 其他苯胺衍生物及其盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

4-氯-3-硝基苯胺文献

Influence of strain and sex on the metabolic profile of rats in repeated dose toxicological studies.

Toxicol. Lett. 191(1) , 88-95, (2009)

The impact of the strain on the metabolite profile of plasma samples in rats dosed with 2500 ppm 2-methyl-4-chlorophenoxyacetic acid (MCPA acid) or 45 mg/kg bw/day 4-chloro-3-nitroaniline (4C3N) for 4...

Subchronic oral toxicology of 4-chloro-3-nitroaniline in the rat.

Fundam. Appl. Toxicol. 6(3) , 551-8, (1986)

4-Chloro-3-nitroaniline was given to groups of 20 male and 20 female rats by gavage at doses of 3.6, 18, or 90 mg/kg in a 10% corn oil suspension. Doses were administered 5 days per week for 90 days. ...

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