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(S)-Baclofen hydrochloride

(S)-Baclofen hydrochloride名称

[ CAS 号 ]:
63701-56-4

[ 英文名 ]:
(S)-Baclofen hydrochloride

[英文别名 ]:

UNII-799SU69U5P
S(-)-Baclofen hydrochloride
(-)-Baclofen hydrochloride
l-Baclofen hydrochloride

(S)-Baclofen hydrochloride物理化学性质

[ 沸点 ]:
364.3ºC at 760mmHg

[ 熔点 ]:
223 - 224 °C

[ 分子式 ]:
C₁₀H₁₃Cl₂NO₂

[ 分子量 ]:
250.12200

[ 闪点 ]:
174.1ºC

[ 精确质量 ]:
249.03200

[ PSA ]:
63.32000

[ LogP ]:
3.35930

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
室温

(S)-Baclofen hydrochlorideMSDS

(S)-Baclofen hydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5084400

CHEMICAL NAME :: Hydrocinnamic acid, beta-(aminomethyl)-p-chloro-, hydrochloride, (S)-

CAS REGISTRY NUMBER :: 63701-56-4

LAST UPDATED :: 198503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-Cl-N-O2.Cl-H

MOLECULAR WEIGHT :: 250.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,187,1980

(S)-Baclofen hydrochloride安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
MW5084400

(S)-Baclofen hydrochloride合成路线

(S)-Baclofen hydrochloride上下游产品

(S)-Baclofen hydrochloride上游产品

(S)-Baclofen hydrochloride下游产品

(S)-Baclofen hydrochloride文献

Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat.

Eur. J. Pharmacol. 196 , 267, (1991)

In a previous study it was found that i.t. administration of L-baclofen decreased arterial pressure and heart rate while D-baclofen differentially increased arterial pressure. The objective of the pre...

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

J. Neurochem. 47 , 898, (1986)

The affinities of a number of analogues of gamma-aminobutyric acid (GABA) for GABAA and GABAB receptor sites and GABA uptake were studied using rat brain membrane preparations. Studies on the (S)-(+)-...

3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.

Pol. J. Pharmacol. Pharm. 32 , 187, (1980)

Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enanti...

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