4-(3-AZASPIRO(5.5)UNDEC-3-YL)-4′-FLUORO-BUTYROPHENONE HYDROCHLORIDE
名称
[ CAS 号 ]:
64-60-8
[ 英文名 ]:
4-(3-AZASPIRO(5.5)UNDEC-3-YL)-4′-FLUORO-BUTYROPHENONE HYDROCHLORIDE
物理化学性质
[ 沸点 ]:
449.6ºC at 760 mmHg
[ 分子式 ]:
C20H29ClFNO
[ 分子量 ]:
353.90200
[ 闪点 ]:
225.7ºC
[ 精确质量 ]:
353.19200
[ PSA ]:
20.31000
[ LogP ]:
5.57480
毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EU1139350
- CHEMICAL NAME :
- Butyrophenone, 4-(3-azaspiro(5.5)undec-3-yl)-4'-fluoro-, hydrochloride
- CAS REGISTRY NUMBER :
- 64-60-8
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H28-F-N-O.Cl-H
- MOLECULAR WEIGHT :
- 353.95
- WISWESSER LINE NOTATION :
- T6N DXTJ A3VR DF& D-& AL6XTJ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,62,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - analgesia
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,62,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,62,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - analgesia
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,62,1965
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