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(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[A,D]环庚烯-10-醇

名称

[ CAS 号 ]:
64520-05-4

[ 中文名 ]:
(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇

[ 英文名 ]:
amitriptyline metabolite (+/-)-

[英文别名 ]:

物理化学性质

[ 密度 ]:
1.151g/cm3

[ 沸点 ]:
453.3ºC at 760mmHg

[ 熔点 ]:
97-99 °C

[ 分子式 ]:
C₂₀H₂₃NO

[ 分子量 ]:
293.40300

[ 闪点 ]:
225.4ºC

[ 精确质量 ]:
293.17800

[ PSA ]:
23.47000

[ LogP ]:
3.65950

[ 外观性状 ]:
solid | white

[ 折射率 ]:
1.651

[ 水溶解性 ]:
0.1 M HCl: soluble

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

合成路线

详细合成路线

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文献

Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.

Clin. Pharmacol. Ther. 52(4) , 350-8, (1992)

In 26 hospitalized patients with depression, a combined pharmacogenetic test with dextromethorphan, a substrate of cytochrome P450IID6, and mephenytoin, the S-form of which is hydroxylated by a P450II...

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.

Drug Metab. Dispos. 9(6) , 565-8, (1981)

The rates of demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline by microsomes from adult human livers were determined by use of mass-fragmentographic or liqui...

CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies.

Forensic Sci. Int. 158(2-3) , 177-83, (2006)

In a series of 202 postmortem toxicology cases, the CYP2D6 and CYP2C19 genes were genotyped, and the concentrations of amitriptyline (AT) and six metabolites were analyzed. The polymorphic CYP2D6 and ...

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