Saframycin A
Saframycin A用途
A heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.
Saframycin A名称
[ CAS 号 ]:
66082-27-7
[ 英文名 ]:
Saframycin A
Saframycin A物理化学性质
[ 密度 ]:
1.44g/cm3
[ 分子式 ]:
C29H30N4O8
[ 分子量 ]:
562.57000
[ 精确质量 ]:
562.20600
[ PSA ]:
163.18000
[ LogP ]:
0.11728
[ 折射率 ]:
1.632
Saframycin A毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VN2265000
- CHEMICAL NAME :
- Saframycin A
- CAS REGISTRY NUMBER :
- 66082-27-7
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C29-H30-N4-O8
- MOLECULAR WEIGHT :
- 562.63
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4900 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3300 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 160 ug/L
- REFERENCE :
- GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
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