<生产厂家价格>

丙谷胺

丙谷胺用途

Proglumide 是已知的胆囊收缩素 (CCK) 拮抗剂。

丙谷胺名称

[ CAS 号 ]:
6620-60-6

[ 中文名 ]:
丙谷胺

[ 英文名 ]:
Proglumide

[中文别名 ]:

二丙谷酰胺

[英文别名 ]:

Proglumide
N-Benzoyl-N',N'-di-n-propyl-DL-isoglutamine
Xyde
(RS)-proglumide
N-Benzoyl-N,N-dipropyl-α-glutamine
DL-4-Benzamido-N,N-dipropylglutaramic Acid
N-Benzoyl-N',N'-dipropyl-DL-isoglutamine
(±)-proglumide
Gastrotopic
MFCD00055071

丙谷胺生物活性

[ 描述 ]:

Proglumide 是已知的胆囊收缩素 (CCK) 拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体

研究领域 >> 癌症

[ 靶点 ]

CCK[1]

[参考文献]

[1]. Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus.

[相关活性小分子]

丙谷胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
589.8±45.0 °C at 760 mmHg

[ 熔点 ]:
148.5--152ºC

[ 分子式 ]:
C₁₈H₂₆N₂O₄

[ 分子量 ]:
334.410

[ 闪点 ]:
310.5±28.7 °C

[ 精确质量 ]:
334.189270

[ PSA ]:
86.71000

[ LogP ]:
2.53

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
通风低温干燥

丙谷胺MSDS

详细MSDS(安全技术说明书)

丙谷胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA2805000

CHEMICAL NAME :: Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL-

CAS REGISTRY NUMBER :: 6620-60-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C18-H26-N2-O4

MOLECULAR WEIGHT :: 334.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5190 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Endocrine - other changes Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 58,3653,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5190 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Endocrine - other changes Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 58,3653,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 69 gm/kg/30D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 546 gm/kg/26W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in pituitary weight Blood - changes in leukocyte (WBC) count

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 327600 mg/kg/26W-C

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1350 mg/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,225,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5400 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,225,1971

丙谷胺安全信息

[ 海关编码 ]:
2924299090

丙谷胺合成路线

详细合成路线

丙谷胺上下游产品

丙谷胺上游产品

丙谷胺下游产品

丙谷胺制备

【方法一】
以谷胺酸为起始原料，经与苯甲酰氯反应得N-苯甲酰谷氨酸，然后乙酐反应得N-苯甲酰谷氨酸酐，再与二丙胺进行胺化反应即得丙谷胺。以谷氨酸计，总收率26-30%。

丙谷胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

丙谷胺