异丙醇_MSDS_用途_密度_异丙醇CAS号【67-63-0】

【用途一】
主要用于制药，也用作溶剂、萃取剂、防冻剂等
【用途二】
用作实验用化学试剂及色谱分析试剂
【用途三】
异丙醇是农药生产的重要中间体，可以生产杀菌剂稻瘟灵、异稻瘟净等，杀虫杀螨剂胺丙畏、水胺硫磷、甲基异柳磷、残杀威、氰戊菊酯等，以及除草剂异丙草胺，并可制备溴代异丙烷和氯代异丙烷，也是农药的重要中间体。
【用途四】
萃取溶剂，载体溶剂。GB 2760-1996：暂时允许使用的食品用香料。用于甜菜糖、糖果、营养增补片剂、酒花萃取、柠檬油、香辛料油树脂、酵母等加工。
【用途五】
作为有机原料和溶剂有着广泛用途。作为化工原料，可生产丙酮、过氧化氢、甲基异丁基酮、二异丁基酮、异丙胺、异丙醚、异丙醇醚、异丙基氯化物，以及脂肪酸异丙酯和氯代脂肪酸异丙酯等。在精细化工方面，可用于生产硝酸异丙酯，黄原酸异丙酯、亚磷酸三异丙酯、三异丙醇铝以及医药和农药等。作为溶剂，可用于生产涂料、油墨、萃取剂、气溶胶剂等。还可用作防冻剂、清洁剂、调和汽油的添加剂、颜料生产的分散剂、印染工业的固定剂、玻璃和透明塑料的防雾剂等。
【用途六】
杂酚油、虫胶、树脂、树胶、硝基纤维素的溶剂。酯化分析测定植物油的溶剂, 测定钡、钙、铜、镁、镍、钾、钠及锶。亚硝酸钴钠-异丙醇法测定土壤及植株含钾量，萃取生物碱，农药分析等。有机合成。抗冻液组合。

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
73.0±3.0 °C at 760 mmHg

[ 熔点 ]:
-89.5 °C

[ 分子式 ]:
C₃H₈O

[ 分子量 ]:
60.095

[ 闪点 ]:
11.7±0.0 °C

[ 精确质量 ]:
60.057514

[ PSA ]:
20.23000

[ LogP ]:
0.16

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
2.1 (vs air)

[ 蒸汽压 ]:
81.3±0.2 mmHg at 25°C

[ 折射率 ]:
1.376

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 水溶解性 ]:
miscible

[ 凝固点 ]:
-89.5℃

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NT8050000

CHEMICAL NAME :: Isopropyl alcohol

CAS REGISTRY NUMBER :: 67-63-0

BEILSTEIN REFERENCE NO. :: 0635639

LAST UPDATED :: 199712

DATA ITEMS CITED :: 90

MOLECULAR FORMULA :: C3-H8-O

MOLECULAR WEIGHT :: 60.11

WISWESSER LINE NOTATION :: QY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14432 mg/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 5272 mg/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - chronic pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 3570 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 13 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 1375 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5045 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16000 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2735 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1088 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12800 ppm/3H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4477 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1509 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1537 mg/kg

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1024 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 6 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1963 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6410 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 667 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 3444 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - general anesthetic Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 mL/kg/7D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Effect on specific coenzyme - B vitamins including folate

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/4H/17W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8000 ppm/8H/20W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5000 ppm/6H/90D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ppm/6H/2Y-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10000 ppm/6H/11D-I

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - ataxia Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 ppm/6H/13W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Liver - changes in liver weight Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 ppm/6H/13W-I

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - ataxia Liver - changes in liver weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5000 ppm/6H/78W-I

TOXIC EFFECTS :: Brain and Coverings - changes in brain weight Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 11340 mg/kg

SEX/DURATION :: female 45 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5040 mg/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 32400 ug/kg

SEX/DURATION :: female 26 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3500 gm/kg

SEX/DURATION :: multigeneration

TOXIC EFFECTS :: Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 3500 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 10000 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 7000 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6240 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

MUTATION DATA

TEST SYSTEM :: Rodent - rat

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(7),33,1981 *** REVIEWS *** ACGIH TLV-STEL 1230 mg/m3 (500 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 983 mg/m3 (400 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,223,1977 IARC Cancer Review:Human Inadequate Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,229,1987 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,229,1987 TOXICOLOGY REVIEW JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 20,428,1938 TOXICOLOGY REVIEW CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955- Volume(issue)/page/year: 19,361,1973 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 400 ppm (980 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,141,1971 OSHA PEL (Gen Indu):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 400 ppm (980 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 400 ppm (980 mg/m3);STEL 500 ppm (1225 mg/m3) JAN 1993 OEL-BELGIUM:TWA 400 ppm (985 mg/m3);STEL 500 ppm (1230 mg/m3) JAN 1993 OEL-DENMARK:TWA 200 ppm (490 mg/m3);Skin JAN 1993 OEL-FRANCE:STEL 400 ppm (980 mg/m3) JAN 1993 OEL-GERMANY:TWA 400 ppm (980 mg/m3) JAN 1993 OEL-JAPAN:STEL 400 ppm (980 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 400 ppm (980 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 400 ppm (980 mg/m3) JAN 1993 OEL-RUSSIA:STEL 400 ppm (10 mg/m3) JAN 1993 OEL-SWEDEN:TWA 150 ppm (350 mg/m3);STEL 250 ppm (600 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 400 ppm (980 mg/m3);STEL 800 ppm JAN 1993 OEL-TURKEY:TWA 200 ppm (500 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 400 ppm (980 mg/m3);STEL 500 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ISOPROPYL ALCOHOL-air:10H TWA 400 ppm;STEL 500 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40987 No. of Facilities: 213605 (estimated) No. of Industries: 465 No. of Occupations: 252 No. of Employees: 3183554 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40987 No. of Facilities: 183402 (estimated) No. of Industries: 449 No. of Occupations: 278 No. of Employees: 4665524 (estimated) No. of Female Employees: 2058264 (estimated)

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H336

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
11-36-67-40-10-36/38

[ 安全声明 (欧洲) ]:
S7-S16-S24/25-S26-S36/37

[ 危险品运输编码 ]:
UN 1219 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
NT8050000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2905122000

详细合成路线

异丙醇上游产品

异丙醇下游产品

1.间接水合法：将含丙稀50%以上的原料气通入吸收塔，在50℃和低压下用75%-85%的浓硫酸进行吸收反应，生成硫酸氢异丙酯。加水将吸收液稀释到硫酸含量为35%后，在解吸塔中用低压蒸汽将硫酸氢异丙酯水解成异丙醇。经粗蒸塔馏到异丙醇与水的共沸组成，含异丙醇87%左右。再继续用蒸馏塔蒸浓到95%，用苯萃取、分离水后再蒸馏，可得含异丙醇99%以上的成品。

该法特点是对丙烯的纯度要求不高，而且丙烯转化率可达50%-60%，可减少精制费用。但耗用硫酸量大，而且存在设备腐蚀和40%的废硫酸的浓问题。

2.直接水合法：将丙烯和水分别加压到1.96MPa，并预热到200℃,混合后加入反应器,进行水合反应.反应器内装有磷酸硅藻土催化剂,反应温度为95℃,压力为0.96MPa，水与丙烯的摩尔比为0.7：1，丙烯的单程转化率为5.2%，选择性为99%。反应气体经中和换热后送到高压冷却器和高压分离器，气相中的异丙醇在回收塔中用脱离子水喷淋回收，末反应的气体经循环压缩机加压后循环使用（保持循环系统中丙烯含量85%）。液相为低浓度异丙醇（15%-17%），经粗蒸塔蒸馏得85%-87%的异丙醇水溶液，再经蒸馏塔蒸浓到95%，然后用苯萃取提浓到99%以上。

与丙烯硫酸水合法相比，本法不用硫酸，不存在腐蚀设备问题，工艺流程简单；但丙烯单程转化率低，丙烯循环量太大，而且要求原料丙烯纯度达99.5%。为了克服丙烯直接水合法的缺点，以95%的丙烯为原料，反应温度240-270℃，反应压力14.7-19.6MPa，水与丙烯的摩尔为水过量。丙烯转化率为60%-70%，异丙醇选择性为99%，异丙烯精馏制后纯度可达99.9%以上，副产物为二异丙醚。此外，采用分子筛催化丙烯水合制异丙醇也是非常有前途的改进工艺方法。

3.将含丙烯50%以上的原料气，在50℃和低压下用75%～85%的浓硫酸进行吸收反应，生成硫酸氢异丙酯。再将硫酸氢异丙酯水解成异丙醇。经粗蒸用蒸馏塔蒸浓到95%，再用苯萃取、分离水后再蒸馏，可得含异丙醇99%以上的成品。或者将丙烯和水分别加压到1.96MPa，并预热到200℃，混合后加入反应器，进行水合反应。反应气体经中和换热后送到高压冷却器和高压分离器，气相中的异丙醇在回收塔中用脱离子水喷淋回收，经粗蒸塔蒸馏得85%～87%的异丙醇水溶液，再经蒸馏塔蒸浓到95%，然后用苯萃取得99%以上的异丙醇。

4.以工业品异丙醇为原料，在每升原料中加入200g新鲜的氧化钙，进行回流，数小时后蒸馏，以除去大部分水，然后在所收集的馏出液中加入氢化钙、氧化钡、钙、无水硫酸铜或5A分子筛，充分振后，静置48h，分出固体干燥剂后蒸馏，即可得纯品。

5.以95%的丙烯和过量水为原料，在钨系催化剂（如硅酸钨）存在下，于240～270℃，14.7～19.6MPa条件下进行反应：

所得异丙醇，精制后纯度可达99.9%以上。

6.先将过量的丙烯和水分别加压至2MPa ，预热至200℃。然后混合，送入反应器反应，催化剂为磷酸硅藻土。控制反应温度195℃，压力维持2MPa，反应结束后，气体先经中和然后进行高压冷却冷凝并气液分离，未反应气体，可循环使用。所得液体为浓度较低的粗异丙醇。经二次蒸馏浓度达95%，然后用苯萃取提浓可达99%以上。

[ 海关编码 ]: 2905122000

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