维生素D3
维生素D3用途
维生素D3名称
[ CAS 号 ]:
67-97-0
[ 中文名 ]:
维生素 D3
[ 英文名 ]:
Vitamin D3
[中文别名 ]:
[英文别名 ]:
- Oxarol
- Vitamin D3
- Ebivit
- Cholecalciferolum
- (3S,5Z,7E)-9,10-Secocholesta-5,7,10-trien-3-ol
- Micro-Dee
- Deparal
- FeraCol
- MFCD00078131
- 9,10-secocholesta-5,7,10-trien-3-ol, (3S,5Z,7E)-
维生素D3生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
Human Endogenous Metabolite
[参考文献]
[相关活性小分子]
维生素D3物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
496.4±24.0 °C at 760 mmHg
[ 熔点 ]:
83-86 °C(lit.)
[ 分子式 ]:
C27H44O
[ 分子量 ]:
384.638
[ 闪点 ]:
214.2±15.1 °C
[ 精确质量 ]:
384.339203
[ PSA ]:
20.23000
[ LogP ]:
9.72
[ 外观性状 ]:
结晶
[ 蒸汽压 ]:
0.0±2.9 mmHg at 25°C
[ 折射率 ]:
1.523
[ 储存条件 ]:
2~8°C
维生素D3MSDS
维生素D3毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VS2900000
- CHEMICAL NAME :
- 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol
- CAS REGISTRY NUMBER :
- 67-97-0
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C27-H44-O
- MOLECULAR WEIGHT :
- 384.71
- WISWESSER LINE NOTATION :
- L56 FYTJ A1 BY1&3Y1&1 FU2U- BL6YYTJ AU1 DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 39 mg/kg/34W-I
- TOXIC EFFECTS :
- Behavioral - anorexia (human) Behavioral - irritability Gastrointestinal - decreased motility or constipation
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 295,1173,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 43,125,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 43(255-256),14,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 136 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 31,105,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - other changes
- REFERENCE :
- JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 193,211,1988 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 12-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- FOMOAJ Folia Morphologica (Warsaw). (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland) V.1- 1929- Volume(issue)/page/year: 29,333,1970 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80574 No. of Facilities: 179 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 6614 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80574 No. of Facilities: 2284 (estimated) No. of Industries: 12 No. of Occupations: 36 No. of Employees: 85071 (estimated) No. of Female Employees: 59178 (estimated)
维生素D3安全信息
[ 符号 ]:
GHS06, GHS08
[ 信号词 ]:
Danger
[ 危害声明 ]:
H301 + H311-H330-H372
[ 警示性声明 ]:
P260-P280-P284-P301 + P310-P310
[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T+:Verytoxic;
[ 风险声明 (欧洲) ]:
R24/25;R26;R48/25
[ 安全声明 (欧洲) ]:
S28-S36/37-S45-S28A
[ 危险品运输编码 ]:
UN 2811 6.1/PG 2
[ WGK德国 ]:
2
[ RTECS号 ]:
VS2900000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1
[ 海关编码 ]:
2936240000
维生素D3合成路线
维生素D3上下游产品
维生素D3上游产品
维生素D3下游产品
维生素D3制备
1.将7-脱氢胆固醇溶于乙醇,用紫外光照射开环,反应液浓缩、冷冻、过滤,滤液通氮减压浓缩至干,得粗维生素D3液。再经精制而得维生素D3。
2.从植物油或酵母中提取人体不能吸收的7-脱氢胆固醇,溶于氯仿或环己烷,用紫外线照射转化成维生素
D3
3.将7-脱氢胆固醇溶于乙醇,用紫外光照射开环,反应液浓缩、冷冻、过滤,滤液通氮减压浓缩至干,得粗维生素D3,再经精制即可。
维生素D3海关
[ 海关编码 ]: 2936240000
维生素D3文献
J. Anim. Sci. 93 , 3018-33, (2015)
A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting...
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.Chem. Res. Toxicol. 23 , 171-83, (2010)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
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产品详情:维生素D3
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¥248.0/1g
¥238.0/20mg
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价格:
¥769.0/5g
¥需询单/1g
¥需询单/1g
¥需询单/1g
联系人:李先生
产品详情:Vitamin D3
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥410.9/250mg
¥137.9/1g
¥482.9/5g
¥1046.9/1ml
联系人:阿拉丁
产品详情:维生素D3
公司名:上海创赛科技有限公司
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联系人:夏言
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相关化合物
【维生素D3】化源网提供维生素D3CAS号67-97-0,维生素D3MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询维生素D3上化源网,专业又轻松。>>电脑版:维生素D3
标题:维生素D3_MSDS_用途_密度_维生素D3CAS号【67-97-0】_化源网 地址:https://www.chemsrc.com/amp/cas/67-97-0_1101696.html