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2-氟丙二酸二乙酯

2-氟丙二酸二乙酯用途

用作医药、新型材料等中间体。

2-氟丙二酸二乙酯名称

[ CAS 号 ]:
685-88-1

[ 中文名 ]:
2-氟丙二酸二乙酯

[ 英文名 ]:
Diethyl fluoromalonate

[中文别名 ]:

[英文别名 ]:

MFCD00009139
EINECS 211-684-7
diethyl 2-fluoropropanedioate

2-氟丙二酸二乙酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
222.3±0.0 °C at 760 mmHg

[ 分子式 ]:
C₇H₁₁FO₄

[ 分子量 ]:
178.158

[ 闪点 ]:
62.2±0.0 °C

[ 精确质量 ]:
178.064133

[ PSA ]:
52.60000

[ LogP ]:
0.61

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.401

[ 储存条件 ]:
室温，密封

2-氟丙二酸二乙酯MSDS

2-氟丙二酸二乙酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO1670000

CHEMICAL NAME :: Malonic acid, fluoro-, diethyl ester

CAS REGISTRY NUMBER :: 685-88-1

BEILSTEIN REFERENCE NO. :: 1775686

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H11-F-O4

MOLECULAR WEIGHT :: 178.18

WISWESSER LINE NOTATION :: 2OVYFVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,169,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 6,169,1961

2-氟丙二酸二乙酯安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S25

[ 危险品运输编码 ]:
UN 3265 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
OO1670000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2917190090

2-氟丙二酸二乙酯合成路线

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2-氟丙二酸二乙酯海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

2-氟丙二酸二乙酯文献

Palladium-catalyzed arylation of malonates and cyanoesters using sterically hindered trialkyl- and ferrocenyldialkylphosphine ligands.

J. Org. Chem. 67(2) , 541-55, (2002)

Palladium-catalyzed reactions of aryl bromides and chlorides with two common stabilized carbanions-enolates of dialkyl malonates and alkyl cyanoesters-are reported. An exploration of the scope of thes...

Fluorinated probes to measure carboxylesterase activities using 19F NMR spectroscopy: application to erythrocytes and Helicobacter pylori.

Arch. Biochem. Biophys. 305(2) , 252-60, (1993)

Eight fluorinated compounds were tested as putative probes to measure carboxylesterase activity employing 19F nuclear magnetic resonance spectroscopy. The method takes advantage of the sensitivity of ...

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