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吡啶-N-氧化物

吡啶-N-氧化物用途

1. N-氧化吡啶为重要的有机合成中间体，在医药工业中常用于抗菌素等药物的合成，如头孢匹林的合成。

吡啶-N-氧化物名称

[ CAS 号 ]:
694-59-7

[ 中文名 ]:
吡啶-N-氧化物

[ 英文名 ]:
pyridine oxide

[中文别名 ]:

[英文别名 ]:

Pyridine 1-oxide
Pyridine-N-Oxidee
EINECS 211-774-6
Pyridine, 1-oxide
Pyridne-N-Oxide
Pyridine N-oxide
Pyridin-N-oxid
Pyridine-N-Oxide
PyridineN-oxide
MFCD00006194

吡啶-N-氧化物物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
270.0±9.0 °C at 760 mmHg

[ 熔点 ]:
62-67 °C(lit.)

[ 分子式 ]:
C₅H₅NO

[ 分子量 ]:
95.099

[ 闪点 ]:
117.1±18.7 °C

[ 精确质量 ]:
95.037117

[ PSA ]:
25.46000

[ LogP ]:
-1.20

[ 外观性状 ]:
白色或淡黄色固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.517

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
soluble

吡啶-N-氧化物MSDS

吡啶-N-氧化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6410000

CHEMICAL NAME :: Pyridine-1-oxide

CAS REGISTRY NUMBER :: 694-59-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H5-N-O

MOLECULAR WEIGHT :: 95.11

WISWESSER LINE NOTATION :: T6NJ AO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1425 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 16,472,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04070

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 48,371,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 594 mg/kg/5D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 85,173,1996

吡啶-N-氧化物安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S24/25-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UT6410000

[ 海关编码 ]:
29333999

吡啶-N-氧化物合成路线

吡啶-N-氧化物上下游产品

吡啶-N-氧化物上游产品

吡啶-N-氧化物下游产品

吡啶-N-氧化物制备

1.用过氧邻苯二甲酸氧化吡啶制取。

2.在装有搅拌器、温度计和滴液漏斗的1升三颈瓶中，放入110克(1.39摩尔)吡啶，在搅拌及保持85℃的条件下，加入250的毫升(285克，1.50摩尔)40%物过氧乙酸(用10%或20%过氧乙酸亦可)。需事50一60分钟加完。继续搅拌直至混合物温度降至40用碘化钾溶液检查乙酸证明不含过氧化物时，在水汽浴上及水泵减压下蒸发乙酸溶液。残余物(180一190克)在》1mm压力下蒸馏，收集固体蒸出物。真空泵必需用干冰冷阱保护(冷阱中可能收集吡啶氧化物乙酸盐在低压下离解产生的约60毫升乙酸)。用油浴加热，不要让温度升到130℃以上。得103-110克(78-83%）无色固体。

吡啶-N-氧化物海关

[ 海关编码 ]: 29333999

吡啶-N-氧化物文献

Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles.

Reproduction 150 , 11-20, (2015)

Phosphodiesterases (PDEs) are important regulators of the intracellular cAMP concentration, which is a central second messenger that affects a multitude of intracellular functions. In the ovaries, cAM...

Effects of metal pyrithione antifoulants on freshwater macrophyte Lemna gibba G3 determined by image analysis.

Ecotoxicology 21(4) , 1102-11, (2012)

Copper pyrithione (CuPT(2)) and zinc pyrithione (ZnPT(2)) are two popular antifouling agents that prevent biofouling. Research into the environmental effects of metal pyrithiones has mainly focused on...

General and mild preparation of 2-aminopyridines.

Org. Lett. 12(22) , 5254-7, (2010)

A general and facile one-pot amination procedure for the synthesis of 2-aminopyridines from the corresponding pyridine-N-oxides is presented as a mild alternative to S(N)Ar chemistry. A variety of ami...

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