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丙位己内酯

丙位己内酯用途

γ-Hexalactone 是存在成熟水果中的一种 gamma 内酯。γ-Hexalactone 能引起 DNA 损伤,可作为对氧磷酶 1 的底物 (PON1)。

丙位己内酯名称

[ CAS 号 ]:
695-06-7

[ 中文名 ]:
γ-己内酯

[ 英文名 ]:
γ-Caprolactone

[中文别名 ]:

[英文别名 ]:

4-Hexanolide
γ-Ethyl-γ-butyrolactone
gamma-Hexanolactone
5-Ethyldihydrofuran-2(3H)-one
gamma-caprolactone
5-Ethyldihydrofuran-2(3H)-on
2(3H)-Furanone, 5-ethyldihydro-
5-Ethyldihydro-2(3H)-furanone
MFCD00005401
g-Caprolactone

丙位己内酯生物活性

[ 描述 ]:

γ-Hexalactone 是存在成熟水果中的一种 gamma 内酯。γ-Hexalactone 能引起 DNA 损伤,可作为对氧磷酶 1 的底物 (PON1)。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. E-Nose and GC-MS Reveal a Difference in the Volatile Profiles of White- and Red-Fleshed Peach Fruit. Sensors (Basel). 2018 Mar 2;18(3).

[2]. Bianchi T, et al. Investigation of the aroma of commercial peach (Prunus persica L. Batsch) types by Proton Transfer Reaction-Mass Spectrometry (PTR-MS) and sensory analysis. Food Res Int. 2017 Sep;99(Pt 1):133-146.

[3]. Shangula S, et al. PON1 increases cellular DNA damage by lactone substrates. Arch Toxicol. 2019 Jul;93(7):2035-2043.

丙位己内酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
214.9±8.0 °C at 760 mmHg

[ 熔点 ]:
-18°C

[ 分子式 ]:
C₆H₁₀O₂

[ 分子量 ]:
114.142

[ 闪点 ]:
98.3±0.0 °C

[ 精确质量 ]:
114.068077

[ PSA ]:
26.30000

[ LogP ]:
0.26

[ 外观性状 ]:
无色至淡黄色液体带有一种草本的,甜的气味

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.432

[ 储存条件 ]:
室温

丙位己内酯MSDS

丙位己内酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU4220000

CHEMICAL NAME :: 2(3H)-Furanone, 5-ethyldihydro-

CAS REGISTRY NUMBER :: 695-06-7

BEILSTEIN REFERENCE NO. :: 0107260

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H10-O2

MOLECULAR WEIGHT :: 114.16

WISWESSER LINE NOTATION :: T5OVTJ E2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,791,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,794,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6862 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

丙位己内酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LU4220000

[ 海关编码 ]:
2932209090

丙位己内酯合成路线

丙位己内酯上下游产品

丙位己内酯上游产品

丙位己内酯下游产品

丙位己内酯制备

1. 由环氧乙烷与钠代丙二酸酯反应而得。

2. 烟草：BU，56；BU，14；FC，9， 18；BU，18。用二氯化锡、浓盐酸在85ºC下乙酸溶液中还原山梨酸而得。

丙位己内酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

丙位己内酯文献

Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

J. Med. Chem. 48 , 3808-15, (2005)

The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-ac...

Profile of volatile metabolites in human urine.

Clin. Chem. 17(7) , 592-4, (1971)

The influence of degradation characteristics of hyaluronic acid hydrogels on in vitro neocartilage formation by mesenchymal stem cells.

Biomaterials 30 , 4287-96, (2009)

The potential of mesenchymal stem cells (MSCs) as a viable cell source for cartilage repair hinges on the development of engineered scaffolds that support adequate cartilage tissue formation. Evolving...

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