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喹齐酮

喹齐酮用途

Quazinone, is a phosphodiesterase 3 (PDE3) inhibitor and novel cardiotonic agent with vasodilating properties.

喹齐酮名称

[ CAS 号 ]:
70018-51-8

[ 中文名 ]:
喹齐酮

[ 英文名 ]:
Quazinone (Ro 13-6438)

[英文别名 ]:

MFCD00211176

喹齐酮物理化学性质

[ 密度 ]:
1.57g/cm3

[ 沸点 ]:
345.6ºC at 760 mmHg

[ 分子式 ]:
C₁₁H₁₀ClN₃O

[ 分子量 ]:
235.67000

[ 闪点 ]:
162.8ºC

[ 精确质量 ]:
235.05100

[ PSA ]:
44.70000

[ LogP ]:
1.36370

[ 折射率 ]:
1.746

喹齐酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

喹齐酮文献

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model.

J. Biomol. Screen. 11(5) , 457-68, (2006)

The squamous cell carcinoma HeLa cell line and an epithelial cell line hTERT-RPE with a nonmalignant phenotype were interrogated for HeLa cell selectivity in response to 1267 annotated compounds repre...

Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors.

J. Mol. Cell. Cardiol. 32(10) , 1831-40, (2000)

Nitric oxide (NO) donors increase heart rate (HR) through a guanylyl cyclase-dependent stimulation of the pacemaker current I(f), without affecting basal I(Ca-L). The activity of I(f)is known to be en...

Relaxation of human ureteral smooth muscle in vitro by modulation of cyclic nucleotide-dependent pathways.

Urol. Res. 28(2) , 110-5, (2000)

Phosphodiesterases (PDE) are key enzymes regulating intracellular cyclic nucleotide turnover and, thus, smooth muscle tension. Recent reports have indicated the presence of PDE isoenzymes 1, 2, 4, and...

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喹齐酮

喹齐酮用途

喹齐酮名称

喹齐酮物理化学性质

喹齐酮安全信息

喹齐酮文献

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