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2,4,4′-三氯联苯

2,4,4′-三氯联苯名称

[ CAS 号 ]:
7012-37-5

[ 中文名 ]:
2,4,4′-三氯联苯

[ 英文名 ]:
2,4-dichloro-1-(4-chlorophenyl)benzene

[中文别名 ]:

[英文别名 ]:

2,4-dichloro-1-(4-chlorophenyl)benzene

2,4,4′-三氯联苯物理化学性质

[ 密度 ]:
1.351g/cm3

[ 沸点 ]:
330.3ºC at 760 mmHg

[ 熔点 ]:
206-207℃

[ 分子式 ]:
C₁₂H₇Cl₃

[ 分子量 ]:
257.54300

[ 闪点 ]:
100ºC

[ 精确质量 ]:
255.96100

[ LogP ]:
5.31380

[ 折射率 ]:
1.603

[ 储存条件 ]:
2-8°C

2,4,4′-三氯联苯MSDS

2,4,4′-三氯联苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV8840000

CHEMICAL NAME :: 1,1'-Biphenyl, 2,4,4'-trichloro-

CAS REGISTRY NUMBER :: 7012-37-5

BEILSTEIN REFERENCE NO. :: 1956846

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H7-Cl3

MOLECULAR WEIGHT :: 257.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 273 mg/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 49,301,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg/3D-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other hydrolases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,94,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 224 mg/kg

SEX/DURATION :: female 10-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 68,311,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 224 mg/kg

SEX/DURATION :: female 10-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 26,117,1995

2,4,4′-三氯联苯安全信息

[ 符号 ]:

GHS02, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H315-H336-H373-H410

[ 警示性声明 ]:
P210-P260-P301 + P310-P331-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
N,Xn,F

[ 风险声明 (欧洲) ]:
33-50/53-11

[ 安全声明 (欧洲) ]:
35-60-61-62-33-29-16

[ 危险品运输编码 ]:
UN 2315

[ RTECS号 ]:
DV8840000

[ 包装等级 ]:
II

[ 危险类别 ]:
9

2,4,4′-三氯联苯合成路线

2,4,4′-三氯联苯文献

Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population.

Environ. Int. 51 , 88-96, (2013)

Persistent organic pollutants (POPs) exert harmful effects on cognitive, endocrine and immune functions and bioaccumulate in the environment and human tissues. The aim of this study was to investigate...

Vertical distributions of organochlorine pesticides and polychlorinated biphenyls in an agricultural soil core from the Guanzhong Basin, China.

Environ. Monit. Assess. 187(1) , 4159, (2015)

The concentrations and distributions of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs), and polychlorinated biphenyls (PCBs) in an agricultural soil core in the Guanzhong Basin...

Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221.

Toxicol. Lett. 152(1) , 91-100, (2004)

The effects of polychlorinated biphenyls (PCBs) on human cytochrome P450 aromatase activity in vitro were investigated using a commercially available microsomal fraction obtained from baculovirus infe...

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