竹桃霉素
竹桃霉素名称
[ CAS 号 ]:
7060-74-4
[ 中文名 ]:
竹桃霉素
[ 英文名 ]:
Matromycin (phosphate)
[英文别名 ]:
- Oleandomycin,Dihydrogenphosphat
- Einecs 230-351-7
- oleandomycin standard solution
- oleandomycin,phosphate(1:1)(salt)
- Matromycin (phosphate)
- Oleandomycin,phosphate (1:1)
- Unii-8681H0C27p
- Oleandomycin dihydrate phosphate salt
- matromycin
- oleandomycin,dihydrogenphosphate
竹桃霉素物理化学性质
[ 熔点 ]:
145-147℃
[ 分子式 ]:
C35H64NO16P
[ 分子量 ]:
785.854
[ 精确质量 ]:
785.396301
[ PSA ]:
253.55000
[ LogP ]:
0.97990
[ 储存条件 ]:
0-6°C
竹桃霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RJ9800000
- CAS REGISTRY NUMBER :
- 7060-74-4
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C35-H61-N-O12.H3-O4-P
- MOLECULAR WEIGHT :
- 785.97
- WISWESSER LINE NOTATION :
- T-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 480 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 7,419,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 19 mg/m3/4H/10W-I
- TOXIC EFFECTS :
- Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(11),83,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.4 mg/m3;Skin JAN 1993
竹桃霉素安全信息
[ 危害码 (欧洲) ]:
T+
[ 风险声明 (欧洲) ]:
28
[ 安全声明 (欧洲) ]:
S22;S24/25
[ 危险品运输编码 ]:
UN2811 6.1/PG 2
[ RTECS号 ]:
RJ9800000
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