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(±)-6-氯-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯扎嗪氢溴化物

用途

SKF 81297 是一种有效的选择性多巴胺 D1 受体 (dopamine D1 receptor) 激动剂。

名称

[ CAS 号 ]:
71636-61-8

[ 中文名 ]:
(±)-6-氯-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯骈吖庚因氢溴酸盐

[ 英文名 ]:
(+/-)-4-HYDROXYDEBRISOQUIN

[中文别名 ]:

[英文别名 ]:

C16H16ClNO2
MFCD00153782

生物活性

[ 描述 ]:

SKF 81297 是一种有效的选择性多巴胺 D1 受体 (dopamine D1 receptor) 激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

D1 Receptor

[参考文献]

[1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7.

[2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844.

物理化学性质

[ 密度 ]:
1.299 g/cm3

[ 沸点 ]:
467.3ºC at 760 mmHg

[ 分子式 ]:
C₁₆H₁₇BrClNO₂

[ 分子量 ]:
370.66900

[ 闪点 ]:
236.4ºC

[ 精确质量 ]:
369.01300

[ PSA ]:
52.49000

[ LogP ]:
4.31570

[ 储存条件 ]:
室温，干燥，密封

MSDS

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

合成路线

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文献

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.

PLoS ONE 8(3) , e57054, (2013)

D1 and D2 receptor expressing striatal medium spiny neurons (MSNs) are ascribed to striatonigral ("direct") and striatopallidal ("indirect") pathways, respectively, that are believed to function antag...

Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats.

Eur. J. Neurosci. 32(4) , 579-90, (2010)

Whole-cell patch-clamp recordings of non-N-methyl-d-aspartate glutamatergic excitatory postsynaptic currents (EPSCs) were carried out from cholinergic neurons in slices of basal forebrain (BF) of deve...

更多文献

(±)-6-氯-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-3-苯扎嗪氢溴化物

用途

名称

生物活性

物理化学性质

MSDS

详细MSDS(安全技术说明书)

安全信息

合成路线

详细合成路线

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文献

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