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反式橙花叔醇

反式橙花叔醇用途

Nerolidol 是一种天然膜活性倍半萜,具有抗肿瘤、抗细菌、抗真菌和抗寄生虫的活性。

反式橙花叔醇名称

[ CAS 号 ]:
7212-44-4

[ 中文名 ]:
橙花叔醇

[ 英文名 ]:
Nerolidol

[中文别名 ]:

[英文别名 ]:

HuMbertiol
1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-
MFCD00008911
Nerolidol
EINECS 230-597-5
3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol
cis/trans-Nerolidol
3,7,11-trimethyldodeca-1,6,10-trien-3-ol
FCI-119b
trans,cis-nerblidol

反式橙花叔醇生物活性

[ 描述 ]:

Nerolidol 是一种天然膜活性倍半萜,具有抗肿瘤、抗细菌、抗真菌和抗寄生虫的活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Nerolidol, et al. In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1049-1056.

反式橙花叔醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
276.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-75 °C

[ 分子式 ]:
C₁₅H₂₆O

[ 分子量 ]:
222.366

[ 闪点 ]:
96.1±0.0 °C

[ 精确质量 ]:
222.198364

[ PSA ]:
20.23000

[ LogP ]:
5.32

[ 外观性状 ]:
无色至草黄色糖浆状油性液体。呈玫瑰及苹果香气。有小和dl-两种旋光体。D-橙花叔醇的沸点276℃，相对密度(d2525)0.8816，旋光度[α]+15°~30°，折射率(nD20)1.4795。Dl-橙花叔醇的沸点98～100℃(40 Pa)，相对密度(d18)0.8788，折射率(nD20)1.480l。溶于乙醇、丙二醇、大多数非挥发性油和矿物油，不溶于甘油。天然品存在于苦橙花油、秘鲁香脂油等精油中。

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.480

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
immiscible

反式橙花叔醇MSDS

详细MSDS(安全技术说明书)

反式橙花叔醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR4977000

CHEMICAL NAME :: 1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-

CAS REGISTRY NUMBER :: 7212-44-4

BEILSTEIN REFERENCE NO. :: 1724135

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H26-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),31,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,887,1975

反式橙花叔醇安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319-H410

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
JR4977000

[ 海关编码 ]:
29052290

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反式橙花叔醇制备

1.天然品存在于苦橙花油、秘鲁香脂油等精油中，将秘鲁香脂油或橙花油、甜橙油进行减压分馏，收集98-102℃（5.32×10-2kPa）馏分即得该品。

2. 将秘鲁香脂油或橙花油、甜橙油用真空分馏法，取 98 ～ 102℃[53Pa(0.4 mmHg)] 的馏分制得。

反式橙花叔醇海关

[ 海关编码 ]: 29052290

反式橙花叔醇文献

Comparison of Aroma-Active Volatiles in Oolong Tea Infusions Using GC-Olfactometry, GC-FPD, and GC-MS.

J. Agric. Food Chem. 63 , 7499-510, (2015)

The aroma profile of oolong tea infusions (Dongdingwulong, DDWL; Tieguanyin, TGY; Dahongpao, DHP) were investigated in this study. Gas chromatography-olfactometry (GC-O) with the method of aroma inten...

[Analyze on chemical compositions of Dalbergia odorifera essential oils extracted by CO2-supercritical-fluid-extraction and steam distillation extraction].

Zhong Yao Cai 34(11) , 1725-7, (2011)

To analyze the chemical compositions of Dalbergia odorifera essential oils extacted by CO2-supercritical-fluid-extraction (SFE-CO2) and steam distillation extraction (SD).The essential oils of Dalberg...

Transdermal behaviors comparisons among Evodia rutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo.

Fitoterapia 83(5) , 954-60, (2012)

Evodiamine (EVO) and rutaecapine (RUT), the major active components from Evodia rutaecarpa extract (EE), are recognized as a depended analgesic agent. This study was designed to investigate the effect...

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