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氟磺胺草醚

氟磺胺草醚用途

Fomesafen 是一种有效的选择性原卟啉原 IX 氧化酶 (PPO) 抑制剂。Fomesafen 是一种除草剂,具有低毒性和高选择性的优点。

氟磺胺草醚名称

[ CAS 号 ]:
72178-02-0

[ 中文名 ]:
氟磺胺草醚

[ 英文名 ]:
Fomesafen

[中文别名 ]:

[英文别名 ]:

MFCD01632756
EINECS 276-439-9
fomesafen [ANSI]
Fomesafen
WS1&MVR BNW EOR BG DXFFF
Fomesafene

氟磺胺草醚生物活性

[ 描述 ]:

Fomesafen 是一种有效的选择性原卟啉原 IX 氧化酶 (PPO) 抑制剂。Fomesafen 是一种除草剂,具有低毒性和高选择性的优点。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Li-Xia Zhao, et al. Novel Thiazole Phenoxypyridine Derivatives Protect Maize From Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen. Biomolecules. 2019 Sep 20;9(10):514.

氟磺胺草醚物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
531.4±60.0 °C at 760 mmHg

[ 熔点 ]:
220-221°C

[ 分子式 ]:
C₁₅H₁₀ClF₃N₂O₆S

[ 分子量 ]:
438.763

[ 闪点 ]:
275.2±32.9 °C

[ 精确质量 ]:
437.990021

[ PSA ]:
126.67000

[ LogP ]:
3.58

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

氟磺胺草醚MSDS

氟磺胺草醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2475000

CHEMICAL NAME :: Benzamide, 5-(2-chloro-4-(trifluoromethyl)phenoxy)-N-(methylsulf onyl)-2-nitro-

CAS REGISTRY NUMBER :: 72178-02-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H10-Cl-F3-N2-O6-S

MOLECULAR WEIGHT :: 438.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,433,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,433,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,433,1991

氟磺胺草醚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S2

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CV2475000

[ 海关编码 ]:
2935009016

氟磺胺草醚合成路线

氟磺胺草醚上下游产品

氟磺胺草醚上游产品

氟磺胺草醚下游产品

氟磺胺草醚制备

制备方法一
3,4-二氯三氟甲苯的制备以对氯甲苯为原料，经光氯化、氟化、环氯化三步反应制得。对氯甲苯的侧链氯化需紫外线灯源，适量催化剂，反应温度110～120℃,时间15～20h，得对氯三氯甲苯。其氟化在压力釜中通无水氟化氢，压力1.6MPa，反应4h，并加适量催化剂，对氯三氟甲苯在苯环上氯化需催化剂存在，反应温度70℃，反应结束时物料经稀盐酸处理、分离、有机相水洗、干燥等环节，得3，4-二氯三氟甲苯。
2-氨基-5-羟基苯甲酸的制备邻硝基苯甲酸与10%H2SO4在Pd/C催化剂作用下，于80～100℃、957.6Pa压力下反应20h，得2-氨基-5-羟基苯甲酸。
5-[2-氯-（三氟甲基）苯氧基]-2-氨基苯甲酸的制备 2-氨基-5-羟基苯甲酸与3，4-二氯三氟甲苯缩合，于135℃反应17h，得相应的二苯醚类化合物。
氟磺胺草醚的制备上步产物在甲苯溶液中通入光气，于40～50℃反应2h，得相应氨基酸酐；然后与甲基磺酰胺（盐）在DMF溶剂中，于100℃反应24h，得相应胺解产物；最后在冰醋酸中用浓硝酸和过氧化氢氧化，于70℃反应20h，得氟磺胺草醚。
制备方法二
先合成5-[2-氯-4-（三氟甲基）苯氧基]-2-硝基苯甲酸，与甲磺酰硫代异氰酸酯反应，生成氟磺胺草醚。或与氯化亚砜作用，变成酰氯，再与甲基磺酰胺反应生成氟磺胺草醚。此法较制备方法一更合理。

氟磺胺草醚海关

[ 海关编码 ]: 2935009016

[ 中文概述 ]:
2935009016 氟磺胺草醚,磺草灵,吲唑磺菌胺等〔包括单嘧磺酯,磺草唑胺,三氟啶磺隆钠〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2935009016 methyl (4-aminophenyl)sulfonylcarbamate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:35.0%

氟磺胺草醚文献

The effect of protoporphyrinogen oxidase inhibitors on microsomal and mitochondrial cytochromes.

Obes. Res. 3 Suppl 5 , 785S-788S, (1995)

Neurological dysfunction is a characteristic feature of acute porphyrias, unexplained until now. One of the possible explanations is a deficiency of heme in the central nervous system, caused by a blo...

Occurrence and distribution of sulfonylurea and related herbicides in central Canadian surface waters 2006-2008.

Bull. Environ. Contam. Toxicol. 87(4) , 420-5, (2011)

Surface water sampling in 2006-2008 measured the occurrence of sulfonylureas and related herbicides (SUs) during base flow conditions and wet weather events. Flumetsulam (29.2%), diuron (36.5%) and fo...

Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice.

Toxicol. Appl. Pharmacol. 189(1) , 28-38, (2003)

Hepatic uroporphyria can be readily induced by a variety of treatments in mice of the C57BL strains, whereas DBA/2 mice are almost completely resistant. However, feeding of the protoporphyrinogen oxid...

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