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盐酸甲氧氯普胺

盐酸甲氧氯普胺用途

Metoclopramide HCl是一种选择性的 dopamine D2 receptor 拮抗剂，用于治疗恶心和呕吐。

盐酸甲氧氯普胺名称

[ CAS 号 ]:
7232-21-5

[ 中文名 ]:
盐酸甲氧氯普胺

[ 英文名 ]:
metoclopramide hcl

[中文别名 ]:

[英文别名 ]:

盐酸甲氧氯普胺物理化学性质

[ 沸点 ]:
418.7ºC at 760 mmHg

[ 熔点 ]:
145ºC

[ 分子式 ]:
C₁₄H₂₃Cl₂N₃O₂

[ 分子量 ]:
336.25700

[ 闪点 ]:
207ºC

[ 精确质量 ]:
335.11700

[ PSA ]:
67.59000

[ LogP ]:
3.77650

[ 外观性状 ]:
白色至灰白色粉末

[ 储存条件 ]:
Hygroscopic, Refrigerator, Under Inert Atmosphere

[ 水溶解性 ]:
H2O: soluble

盐酸甲氧氯普胺MSDS

详细MSDS(安全技术说明书)

盐酸甲氧氯普胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ3325000

CHEMICAL NAME :: o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 7232-21-5

LAST UPDATED :: 199707

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C14-H22-Cl-N3-O2.Cl-H

MOLECULAR WEIGHT :: 336.30

WISWESSER LINE NOTATION :: 2N2&2MVR DZ CG FO1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1 mg/kg/2D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Behavioral - muscle contraction or spasticity

REFERENCE :: BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford St., London WC2E 9HD, UK) V.10(10)- 1956- Volume(issue)/page/year: 28,201,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 ug/kg/3D-I

TOXIC EFFECTS :: Behavioral - tremor Behavioral - rigidity (including catalepsy) Behavioral - muscle contraction or spasticity

REFERENCE :: CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 126,23,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1161 mg/kg/2D-I

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 76,817,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 400 ug/kg/16H-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - rigidity (including catalepsy)

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 66,274,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1714 ug/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - rigidity (including catalepsy) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 81,674,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 15 mg/kg/9H-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: CPHADV Clinical Pharmacy. (American Soc. of Hospital Pharmacists, 4630 Montgomery Ave., Bethesda, MD 20814) V.1- 1982- Volume(issue)/page/year: 5,342,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 143 ug/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 12,378,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 85 mg/kg/48W-I

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 315,518,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 475 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4276 No. of Facilities: 97 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 12489 (estimated) No. of Female Employees: 11172 (estimated)

盐酸甲氧氯普胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BZ3325000

[ 海关编码 ]:
29242990

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