碘甲烷

碘甲烷用途

【用途一】
主要用作甲基化试剂，在医药工业中用于碘甲基蛋氨酸(维生素U)、镇痛药、解毒药磷酸系药物的生产
【用途二】
用作分析试剂，也用于制药工业
【用途三】
医药工业用于碘甲基蛋氨酸（维生素U）、镇痛药、解毒药磷敌等药物的生产，还用于有机合成作甲基化试剂、灭火剂等。

碘甲烷名称

[ CAS 号 ]:
74-88-4

[ 中文名 ]:
甲基碘

[ 英文名 ]:
methyl iodide

[中文别名 ]:

[英文别名 ]:

methyl iodide
Methyl iodide [UN2644] [Poison]
CH3I
Jodmethan
I1
EINECS 200-819-5
Iodmethan
UN 2644
methyl iodine
MeI

碘甲烷物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
40.3±3.0 °C at 760 mmHg

[ 熔点 ]:
−64(lit.)

[ 分子式 ]:
CH₃I

[ 分子量 ]:
141.939

[ 闪点 ]:
7.8±10.7 °C

[ 精确质量 ]:
141.927933

[ LogP ]:
1.50

[ 外观性状 ]:
透明至粉红色液体

[ 蒸汽密度 ]:
4.89 (vs air)

[ 蒸汽压 ]:
437.1±0.1 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 水溶解性 ]:
14 g/L (20 ºC)

碘甲烷MSDS

碘甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA9450000

CHEMICAL NAME :: Methane, iodo-

CAS REGISTRY NUMBER :: 74-88-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 61

MOLECULAR FORMULA :: C-H3-I

MOLECULAR WEIGHT :: 141.94

WISWESSER LINE NOTATION :: I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 101 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/m3/57M-C

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 172 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 794 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - other changes Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 51 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,137,1984 *** REVIEWS *** ACGIH TLV-TWA 12 mg/m3 (2 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,213,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,213,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (28 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,166,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (28 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (28 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (28 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (28 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 1 ppm (5.6 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (28 mg/m3);STEL 10 ppm (56 mg/m3);Skin JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (28 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 10 mg/m3 JAN 1993 OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 5 ppm (30 mg/m3);Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (12 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (28 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL IODIDE-air:10H CA TWA 2 ppm (Sk) (1.7 ppm LOQ) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0422 No. of Facilities: 26 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 413 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0422 No. of Facilities: 34 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2182 (estimated) No. of Female Employees: 440 (estimated)

碘甲烷安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H315-H331-H335-H351

[ 警示性声明 ]:
P261-P280-P301 + P310-P311

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R21;R23/25;R37/38;R40

[ 安全声明 (欧洲) ]:
S36/37-S38-S45-S9-S24-S16

[ 危险品运输编码 ]:
UN 2644 6.1/PG 1

[ WGK德国 ]:
1

[ RTECS号 ]:
PA9450000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2903399030

碘甲烷合成路线

碘甲烷上下游产品

碘甲烷上游产品

碘甲烷下游产品

碘甲烷制备

1.由硫酸二甲酯歧化而得：

2.在搅拌下将碘化钾、水和少量碳酸钙混合均匀，加热到60～65℃并保温，然后慢慢滴加理论量的硫酸二甲酯，加完后将温度升至65～70℃，反应的同时蒸出碘甲烷：

蒸出液静置后分层，弃去水层，油层用无水氯化钙干燥脱水后，加入少许碘化钾颗粒精馏，收集41～43℃馏分，即为成品。

3.在A罐中加入赤磷和甲醇，在A罐中加入碘片，用蒸汽加热A罐，使甲醇沸腾蒸发进入A罐，与碘片接触后流回A罐，如此反复至溶液接近无色。然后蒸出，得粗品碘甲烷。过程中要控制加热速度，使反应不至于太激烈。反应式为：

将粗品碘甲烷依次用水、5%碳酸钠和5%硫代硫酸钠各洗涤一次，得无色液体，静置分层，取下层液体用无水氯化钙和少量海波、干碳酸钠密闭避光干燥，然后过滤，即得成品。

碘甲烷海关

[ 海关编码 ]: 2903399030

[ 中文概述 ]:
2903399030 碘甲烷。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:13.0%。最低关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: M.进口商品检验 N.出口商品检验

[ Summary ]:
2903399030 iodomethane。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:5.5%。general tariff:30.0%

碘甲烷文献

Structure and bioactivity of a polysaccharide extracted from protocorm-like bodies of Dendrobium huoshanense.

Int. J. Biol. Macromol. 72 , 664-72, (2014)

The crude polysaccharides of Dendrobium huoshanense were fractionated by anion-exchange chromatography and gel permeation chromatography, giving one homogeneous fraction DHP-4A with molecular weight o...

Characterization and immunomodulatory activity of rice hull polysaccharides.

Carbohydr. Polym. 124 , 150-6, (2015)

Rice hulls (Oryza sativa) are high in carbohydrate content and have been utilized as dietary fiber. The immunomodulatory bioactivity of rice hull polysaccharides (RHPS) has rarely been reported. This ...

Stable chlorine isotope analysis of chlorinated acetic acids using gas chromatography/quadrupole mass spectrometry.

Rapid Commun. Mass Spectrom. 29 , 2341-8, (2015)

The environmental occurrence of chlorinated acetic acids (CAAs) has been extensively studied, but the sources and transport are still not yet fully understood. A promising approach for source apportio...

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碘甲烷