叔丁醇

叔丁醇用途

【用途一】
用作有机溶剂和化工原料，也是制备药物、香料的原料
【用途二】
用作测定分子量的溶剂及色谱分析试剂
【用途三】
用作有机溶剂，也是制备药物、香料的原料
【用途四】
叔丁醇是杀虫剂噻嗪酮、抑食肼、虫酰肼等，杀螨剂哒螨灵，除草剂仲丁灵的重要中间体，叔丁醇钠在农药工业上作为一种重要的醇钠应用，主要用于拟除虫菊酯环合反应。
【用途五】
常代替正丁醇作为涂料和医药的溶剂。用作内燃机燃料添加剂（防止化油器结冰）及抗爆剂。作为有机合成的中间体及生产叔丁基化合物的烷基化原料，可生产甲基丙烯酸甲酯、叔丁基苯酚、叔丁胺等，用于合成药物、香料。叔丁醇脱水可制取纯度99.0-99.9%的异丁烯。
【用途六】
溶剂。制造浮选剂和香料，测定分子量的溶剂，中间体。可以用做清蜡剂、变性酒精的加溶剂，用于稳定氯烃类。叔丁醇分子上的羟基很容易被取代生成叔丁基卤化物或过氧化物，使叔丁醇成为重要的烷基化剂，尤其用于芳香烃和酚类，可生产多种精细化学品，如医药、农药和各种助剂。

叔丁醇名称

[ CAS 号 ]:
75-65-0

[ 中文名 ]:
叔丁醇

[ 英文名 ]:
tert-Butanol

[中文别名 ]:

[英文别名 ]:

2-Propanol, 2-methyl-
tBuOH
tert-butylalcohol
2-Propanol,2-methyl
tert-Butanol
Trimethylcarbinol
1,1-dimethylethanol
2-Methyl-2-propanol
t-Butyl hydroxide
EINECS 200-751-6

叔丁醇物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
84.6±8.0 °C at 760 mmHg

[ 熔点 ]:
23-26 °C(lit.)

[ 分子式 ]:
C₄H₁₀O

[ 分子量 ]:
74.122

[ 闪点 ]:
11.7±0.0 °C

[ 精确质量 ]:
74.073166

[ PSA ]:
20.23000

[ LogP ]:
0.51

[ 外观性状 ]:
无色,无腐蚀性的液体

[ 蒸汽密度 ]:
2.55 (vs air)

[ 蒸汽压 ]:
46.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.395

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Very flammable. Incompatible with strong oxidizing agents, copper, copper alloys, alkali metals, aluminium.

[ 水溶解性 ]:
soluble

叔丁醇MSDS

详细MSDS(安全技术说明书)

叔丁醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EO1925000

CHEMICAL NAME :: tert-Butyl alcohol

CAS REGISTRY NUMBER :: 75-65-0

BEILSTEIN REFERENCE NO. :: 0906698

LAST UPDATED :: 199712

DATA ITEMS CITED :: 48

MOLECULAR FORMULA :: C4-H10-O

MOLECULAR WEIGHT :: 74.14

WISWESSER LINE NOTATION :: QX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 399 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1538 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3559 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Cardiac - pulse rate Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 gm/kg/94D-C

TOXIC EFFECTS :: Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 703 gm/kg/94D-C

TOXIC EFFECTS :: Behavioral - fluid intake Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 146 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1540 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 2000 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 3500 ppm/7H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 103 gm/kg

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 135 gm/kg

SEX/DURATION :: female 6-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20240 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :: Insect - not otherwise specified

REFERENCE :: ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K. Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal, India) V.1- 1983- Volume(issue)/page/year: 5,321,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 303 mg/m3 (100 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 8,627,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 100 ppm (300 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,32,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 100 ppm (300 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 100 ppm (300 mg/m3);STEL 150 ppm (450 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (303 mg/m3);STEL 150 ppm (455 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (150 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-GERMANY:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-SWEDEN:TWA 50 ppm (150 mg/m3);STEL 75 ppm (250 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 100 ppm (300 mg/m3);STEL 200 ppm (600 mg/m3) JAN 1993 OEL-TURKEY:TWA 100 ppm (300 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (300 mg/m3);STEL 150 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO t-BUTYL ALCOHOL-air:10H TWA 100 ppm;STEL 150 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14400 No. of Facilities: 820 (estimated) No. of Industries: 11 No. of Occupations: 25 No. of Employees: 3121 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14400 No. of Facilities: 10682 (estimated) No. of Industries: 128 No. of Occupations: 84 No. of Employees: 171420 (estimated) No. of Female Employees: 26045 (estimated)

叔丁醇安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319-H332-H335-H336

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338-P370 + P378-P403 + P235

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R20

[ 安全声明 (欧洲) ]:
S9-S16-S45-S36/37-S7

[ 危险品运输编码 ]:
UN 1120 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
EO1925000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2905143000

叔丁醇合成路线

详细合成路线

叔丁醇上下游产品

叔丁醇上游产品

叔丁醇下游产品

叔丁醇制备

1.硫酸水合法由异丁烯与硫酸水合：一般是由抽提丁二烯后的混合C4馏分为原料，在0.7MPa、15℃条件下，用60-70%的硫酸酯化，99%的异丁烯被吸收生成叔丁基硫酸脂，然后水解生成叔丁醇，经水蒸气解吸，分去水分，精制提纯而得成品。

2.离子交换树脂水合法混合C4馏分与软水在阳离子交换树脂存在下水合生成叔丁醇，经分层、提浓，得85%叔丁醇。

3.由抽提丁二烯后的混合C4馏分为原料，用60%～70%的硫酸酯化，99%的异丁烯被吸收生成叔丁基硫酸酯，然后水解生成叔丁醇，经水蒸气解吸，分去水分，精制提纯而得成品。或者混合C4馏分与软水在阳离子交换树脂存在下水合生成叔丁醇，经分层、浓缩得叔丁醇。

4.以工业品叔丁醇为原料，先用饱和碳酸氢钠溶液洗涤，再加入10%的氢氧化钠溶液一起回流并蒸馏，馏出液用无水碳酸钾脱水干燥，过滤所得清液中加入新煅烧的氧化钙回流并蒸馏，馏出液中加入酒石酸再进行蒸馏，收集81.5～83.5℃馏分，即为成品。

叔丁醇海关

[ 海关编码 ]: 2905143000

叔丁醇文献

Crystals of Na(+)/K(+)-ATPase with bound cisplatin.

Biochem. Pharmacol. 92(3) , 494-8, (2014)

Cisplatin is the most widely used chemotherapeutics for cancer treatment, however, its administration is connected to inevitable adverse effects. Previous studies suggested that cisplatin is able to i...

Metabolic and tissue-specific regulation of acyl-CoA metabolism.

PLoS ONE 10(3) , e0116587, (2015)

Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family of acyl-CoA synthetases (ACS). Conversely,...

Alveolar-capillary adaptation to chronic hypoxia in the fatty lung.

Acta Physiol. (Oxf.) 213(4) , 933-46, (2015)

Obese diabetic (ZDF fa/fa) rats with genetic leptin resistance suffer chronic lipotoxicity associated with age-related lung restriction and abnormal alveolar ultrastructure. We hypothesized that these...

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叔丁醇