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甲基膦酸二甲酯

甲基膦酸二甲酯用途

【用途一】
广泛用作聚氨酯泡沫塑料、聚氨酯树脂、环氧树脂等材料的添加型阻燃剂

甲基膦酸二甲酯名称

[ CAS 号 ]:
756-79-6

[ 中文名 ]:
甲基膦酸二甲酯

[ 英文名 ]:
Dimethyl methylphosphonate

[中文别名 ]:

甲基磷酸二甲酯

[英文别名 ]:

MFCD00008349
Dimethyl methylphosphonate
EINECS 212-052-3
Methanephosphonic acid, dimethyl ester
Phosphonic acid, P-methyl-, dimethyl ester
[methoxy(methyl)phosphoryl]oxymethane
DMMP

甲基膦酸二甲酯物理化学性质

[ 密度 ]:
1.145

[ 沸点 ]:
181 ºC

[ 分子式 ]:
C₃H₉O₃P

[ 分子量 ]:
124.076

[ 闪点 ]:
156 ºF

[ 精确质量 ]:
124.028931

[ PSA ]:
45.34000

[ LogP ]:
-0.78

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
1.2±0.3 mmHg at 25°C

[ 折射率 ]:
1.413

[ 稳定性 ]:
Stability Combustible. Incompatible with strong oxidizing agents, strong bases. May soften some rubbers or plastics. Hydrolyzes slowly in contact with water.

[ 水溶解性 ]:
>=10 g/100 mL at 21 ºC

甲基膦酸二甲酯MSDS

甲基膦酸二甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SZ9120000

CHEMICAL NAME :: Phosphonic acid, methyl-, dimethyl ester

CAS REGISTRY NUMBER :: 756-79-6

BEILSTEIN REFERENCE NO. :: 0878263

LAST UPDATED :: 199710

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C3-H9-O3-P

MOLECULAR WEIGHT :: 124.09

WISWESSER LINE NOTATION :: 1OPO&1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8210 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6810 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 912 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 3998 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 gm/kg/15D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 gm/kg/15D-C

TOXIC EFFECTS :: Gastrointestinal - gastritis Gastrointestinal - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 gm/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 515 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 63 gm/kg

SEX/DURATION :: male 63 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 126 gm/kg

SEX/DURATION :: male 63 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15750 mg/kg

SEX/DURATION :: male 63 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 61250 mg/kg

SEX/DURATION :: male 7 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33400 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 11 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,15,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1091 No. of Facilities: 35 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 204 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1091 No. of Facilities: 53 (estimated) No. of Industries: 5 No. of Occupations: 8 No. of Employees: 2134 (estimated) No. of Female Employees: 763 (estimated)

甲基膦酸二甲酯安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H319-H340-H361f

[ 警示性声明 ]:
P201-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R36;R46

[ 安全声明 (欧洲) ]:
S53-S26-S45

[ 危险品运输编码 ]:
2810

[ WGK德国 ]:
2

[ RTECS号 ]:
SZ9120000

甲基膦酸二甲酯合成路线

甲基膦酸二甲酯制备

1. 酯交换法

（1）亚磷酸三苯酯亚磷酸三苯酯的制备将苯酚融化后，抽入反应釜，搅拌下保持在40℃下滴加三氯化磷，反应生成亚磷酸三苯酯。副产氯化氢进行吸收处理，粗酯经水洗，静置分去水层，进行减压蒸馏，即得到精制亚磷酸三甲苯酯。

（2）亚磷酸三甲酯的制备亚磷酸三甲苯酯再在碱性催化剂甲醇钠存在下与甲醇进行酯交换反应生成亚磷酸三甲酯。反应产物经分离除去苯酚及残余甲醇后即得精制亚磷酸三甲酯。

（3）甲基膦酸二甲酯的合成甲基膦酸二甲酯亚磷酸三甲酯经异构反应而制得甲基膦酸二甲酯。

2.三氯化磷、甲醇直接酯化法以无水甲醇、三氯化磷和液氨为原料，在二甲苯溶剂存在下进行酯化反应，生成亚磷酸三甲酯，反应在0～10℃温度的条件下进行。制得的粗品经水洗除去氯化铵，再经精馏而得精制亚磷酸三甲酯。亚磷酸三甲酯再经异构化反应而制得甲基膦酸二甲酯。

甲基膦酸二甲酯文献

Tandem differential mobility spectrometry with ion dissociation in air at ambient pressure and temperature.

Analyst 140(9) , 2995-3002, (2015)

Proton-bound dimers were dissociated to protonated monomers in air at ambient pressure and temperature using electric fields of ultrahigh Field Asymmetric Ion Mobility Spectrometry (ultraFAIMS) with t...

Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.

Bioorg. Med. Chem. 22(19) , 5338-44, (2014)

Interleukin (IL)-6 is a proinflammatory cytokine that performs a wide variety of biological functions, including important roles in the progression of chronic inflammatory diseases such as periodontal...

Facility monitoring of chemical warfare agent simulants in air using an automated, field-deployable, miniature mass spectrometer.

Rapid Commun. Mass Spectrom. 25(10) , 1437-44, (2011)

Vapors of four chemical warfare agent (CWA) stimulants, 2-chloroethyl ethyl sulfide (CEES), diethyl malonate (DEM), dimethyl methylphosphonate (DMMP), and methyl salicylate (MeS), were detected, ident...

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